Curing mosquitoes with genetic approaches for malaria control

• Published in: Trends in parasitology Vol. 40; no. 6; pp. 487 - 499
• Main Authors: Kefi, Mary, Cardoso-Jaime, Victor, Saab, Sally A., Dimopoulos, George
• Format: Journal Article
• Language: English
• Published: England Elsevier Ltd 01.06.2024
• Subjects: Animals; Animals, Genetically Modified; Anopheles; Anopheles - genetics; Anopheles - parasitology; genetically modified organisms; Humans; malaria; Malaria - prevention & control; Malaria - transmission; malaria vectors; Mosquito Control - methods; Mosquito Vectors - genetics; Mosquito Vectors - parasitology; parasites; parasitology; Plasmodium; population modification; public health; transgenesis; Plasmodium; malaria vectors; Anopheles; transgenesis; population modification

A population modification approach involves spreading genes/elements through the populations to make mosquitoes refractory to the parasite.Parasite refractoriness of mosquito vectors can be achieved by genetic manipulations of mosquito endogenous effectors and host factors or by introducing exogenou...