Histological assessment of follicular delivery of flutamide by solid lipid nanoparticles: potential tool for the treatment of androgenic alopecia

• Published in: Drug development and industrial pharmacy Vol. 42; no. 6; p. 846
• Main Authors: Hamishehkar, Hamed, Ghanbarzadeh, Saeed, Sepehran, Sasan, Javadzadeh, Yousef, Adib, Zahra Mardhiah, Kouhsoltani, Maryam
• Format: Journal Article
• Language: English
• Published: England 02.06.2016
• Subjects: Administration, Cutaneous; Alopecia - drug therapy; Androgen Antagonists - administration & dosage; Androgen Antagonists - chemistry; Animals; Chemistry, Pharmaceutical - methods; Drug Carriers - administration & dosage; Drug Carriers - chemistry; Drug Delivery Systems - methods; Excipients - administration & dosage; Excipients - chemistry; Flutamide - administration & dosage; Flutamide - chemistry; Hair Follicle - drug effects; Lipids - administration & dosage; Lipids - chemistry; Male; Nanoparticles - administration & dosage; Nanoparticles - chemistry; Particle Size; Rats; Rats, Wistar; Skin - metabolism; Skin Absorption; Androgenic alopecia; Flutamide; transdermal drug delivery; solid lipid nanoparticle

Flutamide is a potent anti-androgen with the several unwanted side effects in systemic administration, therefore, it has attracted special interest in the development of topically applied formulations for the treatment of androgenic alopecia. The purpose of this study was to prepare and characterize...