Pharmacokinetics of long-circulating liposomes

• Published in: Advanced drug delivery reviews Vol. 16; no. 2; pp. 267 - 284
• Main Authors: Allen, Theresa M., Hansen, Christian B., de Menezes, Daniel E.Lopes
• Format: Journal Article
• Language: English
• Published: Elsevier B.V 01.09.1995
• Subjects: Absorption; Biodistribution; Clearance; Elimination; Long-circulating liposomes; Pharmacokinetics; HPI; eggPG; PS; eggPC; Clearance; Biodistribution; AUC; i.V; MPS; Absorption; mPEG; SL; SM; V d; CHOL; G M1; DPPC; HSPC; DOPE; DSPC; DSPE; t 1 2; Elimination; CL; s.c; i.p; Long-circulating liposomes; PA; PEG; PG; PI; Pharmacokinetics; DXR; EPI

Association of drugs with carriers such as liposomes has marked effects on both the pharmacokinetic profiles of the carrier and of the carrier-associated drug. In general, association of drugs with liposomes delays drug absorption, alters and restricts drug biodistribution, decreases the volume of d...