Clostridium perfringens phospholipase C, an archetypal bacterial virulence factor, induces the formation of extracellular traps by human neutrophils

• Published in: Frontiers in cellular and infection microbiology Vol. 13; p. 1278718
• Main Authors: Badilla-Vargas, Lisa, Pereira, Reynaldo, Molina-Mora, José Arturo, Alape-Girón, Alberto, Flores-Díaz, Marietta
• Format: Journal Article
• Language: English
• Published: Switzerland Frontiers Media S.A 27.10.2023
• Subjects: Animals; bacterial pathogenesis; bacterial toxins; Cellular and Infection Microbiology; Clostridium perfringens; Extracellular Traps - metabolism; Gas Gangrene - metabolism; Gas Gangrene - pathology; Humans; NETs; Neutrophils; phospholipase; Proteomics; secretome; Type C Phospholipases - metabolism; phospholipase; NETs; antioxidants; bacterial pathogenesis; bacterial toxins; gas gangrene; secretome; Clostridium perfringens

Neutrophil extracellular traps (NETs) are networks of DNA and various microbicidal proteins released to kill invading microorganisms and prevent their dissemination. However, a NETs excess is detrimental to the host and involved in the pathogenesis of various inflammatory and immunothrombotic diseas...