Occurrence of exercise-induced and spontaneous wide complex tachycardia during therapy with flecainide for complex ventricular arrhythmias: A probable proarrhythmic effect

• Published in: The American heart journal Vol. 113; no. 5; pp. 1071 - 1077
• Main Authors: Anastasiou-Nana, Maria I, Anderson, Jeffrey L, Stewart, James R, Crevey, Barry J, Yanowitz, Frank G, Lutz, Joan R, Johnson, Theresa A
• Format: Journal Article
• Language: English
• Published: New York, NY Mosby, Inc 01.05.1987; Elsevier
• Subjects: Adult; Aged; Biological and medical sciences; Drug toxicity and drugs side effects treatment; Electrocardiography; Female; Flecainide - adverse effects; Heart Ventricles - physiopathology; Humans; Male; Medical sciences; Middle Aged; Pharmacology. Drug treatments; Physical Exertion; Tachycardia - drug therapy; Tachycardia - etiology; Tachycardia - physiopathology; Toxicity: cardiovascular system; Ventricular Fibrillation - physiopathology; Physical exercise; Human; Chemotherapy; Tachycardia; Arrhythmia; Toxicity; Oral administration; Cardiovascular disease; Paroxysmal ventricular tachycardia; Antiarrhythmia agent
• ISSN: 0002-8703; 1097-6744
• DOI: 10.1016/0002-8703(87)90914-8

Flecainide acetate, a new antiarrhythmic agent, possesses favorable pharmacokinetic and hemodynamic properties and demonstrates highly favorable antiarrhythmic activity in patients with ventricular arrhythmias. However, the proarrhythmic potential of flecainide deserves further evaluation. In 7 (13%) of 55 consecutive patients treated with oral flecainide, 200 to 600 mg/day, for complex ventricular arrhythmias (including sustained ventricular tachycardia in 14), we observed the appearance of new or more sustained exercise-induced (five patients) or spontaneous (two patients) wide complex tachycardia. The mechanism of wide complex tachycardia appeared to be ventricular tachycardia in all seven. In our series, episodes were self-remitting or successfully treated. In four patients, wide complex tachycardia did not recur during exercise testing during alternative antiarrhythmic therapy (three patients) or no antiarrhythmic therapy (one patient). These observations raise the possibility of flecainide-related proarrhythmia, manifested as an increased propensity to exercise (activity)-induced wide complex tachycardia, which was not reliably predicted by results of Holter recordings or programmed electrical stimulation. Patients with complex ventricular arrhythmias beginning long-term treatment with oral flecainide should be considered for treadmill exercise testing together with ambulatory monitoring as part of the initial assessment of drug efficacy.