Epithelial Cell Adhesion Molecule (EpCAM) Expression Can Be Modulated via NFκB

The epithelial cell adhesion molecule (EpCAM) is considered an essential proliferation signature in cancer. In the current research study, qPCR induced expression of EpCAM was noted in acute lymphoblastic leukemia (ALL) cases. Costunolide, a sesquiterpene lactone found in crepe ginger and lettuce, i...

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Published inBiomedicines Vol. 10; no. 11; p. 2985
Main Authors Zia, Saadiya, Tehreem, Komal, Batool, Sidra, Ishfaq, Mehreen, Mirza, Shaher Bano, Khan, Shahrukh, Almashjary, Majed N., Hazzazi, Mohannad S., Qanash, Husam, Shaikh, Ahmad, Baty, Roua S., Jafri, Ibrahim, Alsubhi, Nouf H., Alrefaei, Ghadeer I., Sami, Rokayya, Shahid, Ramla
Format Journal Article
LanguageEnglish
Published Switzerland MDPI AG 20.11.2022
MDPI
Subjects
Acute lymphoblastic leukemia
Binding sites
Breast cancer
Cell adhesion & migration
Cell adhesion molecules
Cell cycle
Cell growth
cell proliferation
costunolide
epithelial cell adhesion molecule
Epithelial cells
Gene expression
Herbal medicine
Hydrophobicity
Leukemia
Ligands
Lymphatic leukemia
Medicinal plants
Myc protein
NF-κB protein
Ovaries
Pediatrics
Phosphorylation
Proteins
Skin cancer
Software
Stem cells
Telomerase
telomerase inhibition
Telomeres
Transcription factors
United States > US
costunolide
cell proliferation
acute lymphoblastic leukemia
telomerase inhibition
epithelial cell adhesion molecule
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Abstract The epithelial cell adhesion molecule (EpCAM) is considered an essential proliferation signature in cancer. In the current research study, qPCR induced expression of EpCAM was noted in acute lymphoblastic leukemia (ALL) cases. Costunolide, a sesquiterpene lactone found in crepe ginger and lettuce, is a medicinal herb with anticancer properties. Expression of EpCAM and its downstream target genes (Myc and TERT) wasdownregulated upon treatment with costunolide in Jurkat cells. A significant change in the telomere length of Jurkat cells was not noted at 72 h of costunolide treatment. An in silico study revealed hydrophobic interactions between EpCAM extracellular domain and Myc bHLH with costunolide. Reduced expression of NFκB, a transcription factor of EpCAM, Myc, and TERT in costunolide-treated Jurkat cells, suggested that costunolide inhibits gene expression by targeting NFκB and its downstream targets. Overall, the study proposes that costunolide could be a promising therapeutic biomolecule for leukemia.
AbstractList The epithelial cell adhesion molecule (EpCAM) is considered an essential proliferation signature in cancer. In the current research study, qPCR induced expression of was noted in acute lymphoblastic leukemia (ALL) cases. Costunolide, a sesquiterpene lactone found in crepe ginger and lettuce, is a medicinal herb with anticancer properties. Expression of and its downstream target genes ( and ) wasdownregulated upon treatment with costunolide in Jurkat cells. A significant change in the telomere length of Jurkat cells was not noted at 72 h of costunolide treatment. An in silico study revealed hydrophobic interactions between EpCAM extracellular domain and Myc bHLH with costunolide. Reduced expression of , a transcription factor of , and in costunolide-treated Jurkat cells, suggested that costunolide inhibits gene expression by targeting NFκB and its downstream targets. Overall, the study proposes that costunolide could be a promising therapeutic biomolecule for leukemia.
The epithelial cell adhesion molecule (EpCAM) is considered an essential proliferation signature in cancer. In the current research study, qPCR induced expression of EpCAM was noted in acute lymphoblastic leukemia (ALL) cases. Costunolide, a sesquiterpene lactone found in crepe ginger and lettuce, is a medicinal herb with anticancer properties. Expression of EpCAM and its downstream target genes (Myc and TERT) wasdownregulated upon treatment with costunolide in Jurkat cells. A significant change in the telomere length of Jurkat cells was not noted at 72 h of costunolide treatment. An in silico study revealed hydrophobic interactions between EpCAM extracellular domain and Myc bHLH with costunolide. Reduced expression of NFκB, a transcription factor of EpCAM, Myc, and TERT in costunolide-treated Jurkat cells, suggested that costunolide inhibits gene expression by targeting NFκB and its downstream targets. Overall, the study proposes that costunolide could be a promising therapeutic biomolecule for leukemia.
The epithelial cell adhesion molecule (EpCAM) is considered an essential proliferation signature in cancer. In the current research study, qPCR induced expression of EpCAM was noted in acute lymphoblastic leukemia (ALL) cases. Costunolide, a sesquiterpene lactone found in crepe ginger and lettuce, is a medicinal herb with anticancer properties. Expression of EpCAM and its downstream target genes (Myc and TERT) wasdownregulated upon treatment with costunolide in Jurkat cells. A significant change in the telomere length of Jurkat cells was not noted at 72 h of costunolide treatment. An in silico study revealed hydrophobic interactions between EpCAM extracellular domain and Myc bHLH with costunolide. Reduced expression of NFκB, a transcription factor of EpCAM, Myc, and TERT in costunolide-treated Jurkat cells, suggested that costunolide inhibits gene expression by targeting NFκB and its downstream targets. Overall, the study proposes that costunolide could be a promising therapeutic biomolecule for leukemia.The epithelial cell adhesion molecule (EpCAM) is considered an essential proliferation signature in cancer. In the current research study, qPCR induced expression of EpCAM was noted in acute lymphoblastic leukemia (ALL) cases. Costunolide, a sesquiterpene lactone found in crepe ginger and lettuce, is a medicinal herb with anticancer properties. Expression of EpCAM and its downstream target genes (Myc and TERT) wasdownregulated upon treatment with costunolide in Jurkat cells. A significant change in the telomere length of Jurkat cells was not noted at 72 h of costunolide treatment. An in silico study revealed hydrophobic interactions between EpCAM extracellular domain and Myc bHLH with costunolide. Reduced expression of NFκB, a transcription factor of EpCAM, Myc, and TERT in costunolide-treated Jurkat cells, suggested that costunolide inhibits gene expression by targeting NFκB and its downstream targets. Overall, the study proposes that costunolide could be a promising therapeutic biomolecule for leukemia.
The epithelial cell adhesion molecule (EpCAM) is considered an essential proliferation signature in cancer. In the current research study, qPCR induced expression of EpCAM was noted in acute lymphoblastic leukemia (ALL) cases. Costunolide, a sesquiterpene lactone found in crepe ginger and lettuce, is a medicinal herb with anticancer properties. Expression of EpCAM and its downstream target genes ( Myc and TERT ) wasdownregulated upon treatment with costunolide in Jurkat cells. A significant change in the telomere length of Jurkat cells was not noted at 72 h of costunolide treatment. An in silico study revealed hydrophobic interactions between EpCAM extracellular domain and Myc bHLH with costunolide. Reduced expression of NFκB , a transcription factor of EpCAM , Myc, and TERT in costunolide-treated Jurkat cells, suggested that costunolide inhibits gene expression by targeting NFκB and its downstream targets. Overall, the study proposes that costunolide could be a promising therapeutic biomolecule for leukemia.
Author Shahid, Ramla
Baty, Roua S.
Hazzazi, Mohannad S.
Khan, Shahrukh
Shaikh, Ahmad
Alrefaei, Ghadeer I.
Zia, Saadiya
Jafri, Ibrahim
Alsubhi, Nouf H.
Qanash, Husam
Tehreem, Komal
Ishfaq, Mehreen
Batool, Sidra
Mirza, Shaher Bano
Sami, Rokayya
Almashjary, Majed N.
AuthorAffiliation 1 Department of Biosciences, COMSATS University Islamabad (CUI), Islamabad 45550, Pakistan
4 Department of Medical Laboratory Sciences, Faculty of Applied Medical Sciences, King Abdul Aziz University, Jeddah 22254, Saudi Arabia
8 Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Khalid University, P.O. Box 960, Abha 61421, Saudi Arabia
2 Department of Biochemistry, Faculty of Sciences, University of Agriculture Faisalabad, Faisalabad 38000, Pakistan
10 Biological Sciences Department, College of Science and Arts, King Abdul Aziz University, Rabigh 21911, Saudi Arabia
6 Department of Medical Laboratory Science, College of Applied Medical Sciences, University of Ha’il, Hail 55476, Saudi Arabia
5 Hematology Research Unit, King Fahd Medical Research Center, King Abdul Aziz University, Jeddah 22254, Saudi Arabia
9 Department of Biotechnology, College of Science, Taif University, P.O. Box 11099, Taif 21944, Saudi Arabia
3 Research School of Chemistry, Australian Na
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Issue 11
Keywords costunolide
cell proliferation
acute lymphoblastic leukemia
telomerase inhibition
epithelial cell adhesion molecule
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Snippet The epithelial cell adhesion molecule (EpCAM) is considered an essential proliferation signature in cancer. In the current research study, qPCR induced...
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SubjectTerms Acute lymphoblastic leukemia
Binding sites
Breast cancer
Cell adhesion & migration
Cell adhesion molecules
Cell cycle
Cell growth
cell proliferation
costunolide
epithelial cell adhesion molecule
Epithelial cells
Gene expression
Herbal medicine
Hydrophobicity
Leukemia
Ligands
Lymphatic leukemia
Medicinal plants
Myc protein
NF-κB protein
Ovaries
Pediatrics
Phosphorylation
Proteins
Skin cancer
Software
Stem cells
Telomerase
telomerase inhibition
Telomeres
Transcription factors
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Title Epithelial Cell Adhesion Molecule (EpCAM) Expression Can Be Modulated via NFκB
URI https://www.ncbi.nlm.nih.gov/pubmed/36428553
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Volume 10
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