Liver Fat and Insulin Resistance Are Independently Associated with the −514C>T Polymorphism of the Hepatic Lipase Gene

• Published in: The journal of clinical endocrinology and metabolism Vol. 90; no. 7; pp. 4238 - 4243
• Main Authors: Stefan, Norbert, Schäfer, Silke, Machicao, Fausto, Machann, Jürgen, Schick, Fritz, Claussen, Claus D, Stumvoll, Michael, Häring, Hans-Ulrich, Fritsche, Andreas
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Endocrine Society 01.07.2005
• Subjects: Adult; Biological and medical sciences; Cholesterol, HDL - blood; Cholesterol, LDL - blood; Cross-Sectional Studies; Endocrinopathies; Female; Fundamental and applied biological sciences. Psychology; Humans; Insulin Resistance; Lipase - genetics; Lipid Metabolism; Liver - metabolism; Male; Medical sciences; Polymorphism, Genetic; PPAR gamma - genetics; Vertebrates: endocrinology; Visceral fat; Pancreatic hormone; Genetic variability; Digestive system; Enzyme; Liver; Triacylglycerol lipase; Genotype; Esterases; Insulin; Carboxylic ester hydrolases; Target tissue resistance; Hydrolases; Insulin resistance; Endocrinology; Polymorphism

Context: Liver fat predicts insulin resistance in humans. So far, there is not much information on genetic determinants of liver fat. Hepatic lipase is a liver-specific enzyme that regulates lipid metabolism. Objective: First, our object was to investigate whether the functional −514C>T polymorph...