Analysis of the influence of glutathione S-transferase (GSTM1 and GSTT1) genes on the risk of essential hypertension

• Published in: Annals of human biology Vol. 48; no. 7-8; pp. 585 - 589
• Main Authors: Nassereddine, Sanaa, Habbal, Rachida, Kassogue, Yaya, Kaltoum, Ait Boujmia Oum, Farah, Korchi, Majda, Haraka, Rhizlane, Abou Elfath, Nadifi, Sellama, Dehbi, Hind
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 17.11.2021; Taylor & Francis Group
• Subjects: Case-Control Studies; essential hypertension; Essential Hypertension - genetics; Genetic Predisposition to Disease; Genotype; Glutathione S-transferase; Glutathione Transferase - genetics; GSTM1; GSTT1; Humans; Middle Aged; Morocco; Polymorphism, Genetic; Risk Factors; essential hypertension; GSTT1; GSTM1; Morocco; Glutathione S-transferase
• ISSN: 0301-4460; 1464-5033; 1464-5033
• DOI: 10.1080/03014460.2022.2039291

Essential hypertension (EH) results from a complex interaction between environmental factors and an individual's genetic background. To assess the relationship between polymorphisms in GSTM1 and GSTT1 and the risk of EH. A multiplex-PCR was used to identify the genotypic profiles of GSTM1 and GSTT1 in 160 patients and 210 controls. The frequency of GSTM1-null genotype was higher in patients younger than 61 years when compared to those over 61 years. Interestingly, GSTT1-null was significantly associated with the risk of EH (OR 4; 95% CI 2.6-6.3; p < 0.0001). While GSTM1-null showed no trend (OR 0.7; 95% CI 0.5-1.1, p = 0.12). Individuals carrying the combined GSTT1-null/GSTM1-null were 2.4 times more at risk for hypertension compared to those harbouring the combined GSTT1-present/GSTM1-present genotype (OR 2.4; 95% CI 1.3-4.4; p = 0.005). Additionally, the presence of the combined GSTT1-null/GSTM1-present was associated with an increased risk of EH compared to GSTT1-present/GSTM1-present carriers (OR 6.75; 95% CI 3.4-13.2; p < 0.0001). This study showed that the GSTT1-null alone or in interaction with GSTM1-present or GSTM1-null was associated with a higher risk of hypertension. Moreover, the GSTM1-null seems to be associated with the age of onset of hypertension.