Analysis of the influence of glutathione S-transferase (GSTM1 and GSTT1) genes on the risk of essential hypertension

Essential hypertension (EH) results from a complex interaction between environmental factors and an individual's genetic background. To assess the relationship between polymorphisms in GSTM1 and GSTT1 and the risk of EH. A multiplex-PCR was used to identify the genotypic profiles of GSTM1 and G...

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Published inAnnals of human biology Vol. 48; no. 7-8; pp. 585 - 589
Main Authors Nassereddine, Sanaa, Habbal, Rachida, Kassogue, Yaya, Kaltoum, Ait Boujmia Oum, Farah, Korchi, Majda, Haraka, Rhizlane, Abou Elfath, Nadifi, Sellama, Dehbi, Hind
Format Journal Article
LanguageEnglish
Published England Taylor & Francis 17.11.2021
Taylor & Francis Group
Subjects
Case-Control Studies
essential hypertension
Essential Hypertension - genetics
Genetic Predisposition to Disease
Genotype
Glutathione S-transferase
Glutathione Transferase - genetics
GSTM1
GSTT1
Humans
Middle Aged
Morocco
Polymorphism, Genetic
Risk Factors
essential hypertension
GSTT1
GSTM1
Morocco
Glutathione S-transferase
Online AccessGet full text
ISSN0301-4460
1464-5033
1464-5033
DOI10.1080/03014460.2022.2039291

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Abstract Essential hypertension (EH) results from a complex interaction between environmental factors and an individual's genetic background. To assess the relationship between polymorphisms in GSTM1 and GSTT1 and the risk of EH. A multiplex-PCR was used to identify the genotypic profiles of GSTM1 and GSTT1 in 160 patients and 210 controls. The frequency of GSTM1-null genotype was higher in patients younger than 61 years when compared to those over 61 years. Interestingly, GSTT1-null was significantly associated with the risk of EH (OR 4; 95% CI 2.6-6.3; p < 0.0001). While GSTM1-null showed no trend (OR 0.7; 95% CI 0.5-1.1, p = 0.12). Individuals carrying the combined GSTT1-null/GSTM1-null were 2.4 times more at risk for hypertension compared to those harbouring the combined GSTT1-present/GSTM1-present genotype (OR 2.4; 95% CI 1.3-4.4; p = 0.005). Additionally, the presence of the combined GSTT1-null/GSTM1-present was associated with an increased risk of EH compared to GSTT1-present/GSTM1-present carriers (OR 6.75; 95% CI 3.4-13.2; p < 0.0001). This study showed that the GSTT1-null alone or in interaction with GSTM1-present or GSTM1-null was associated with a higher risk of hypertension. Moreover, the GSTM1-null seems to be associated with the age of onset of hypertension.
AbstractList Background Essential hypertension (EH) results from a complex interaction between environmental factors and an individual’s genetic background. Aim To assess the relationship between polymorphisms in GSTM1 and GSTT1 and the risk of EH. Subjects and methods A multiplex-PCR was used to identify the genotypic profiles of GSTM1 and GSTT1 in 160 patients and 210 controls. Results The frequency of GSTM1-null genotype was higher in patients younger than 61 years when compared to those over 61 years. Interestingly, GSTT1-null was significantly associated with the risk of EH (OR 4; 95% CI 2.6–6.3; p < 0.0001). While GSTM1-null showed no trend (OR 0.7; 95% CI 0.5–1.1, p = 0.12). Individuals carrying the combined GSTT1-null/GSTM1-null were 2.4 times more at risk for hypertension compared to those harbouring the combined GSTT1-present/GSTM1-present genotype (OR 2.4; 95% CI 1.3–4.4; p = 0.005). Additionally, the presence of the combined GSTT1-null/GSTM1-present was associated with an increased risk of EH compared to GSTT1-present/GSTM1-present carriers (OR 6.75; 95% CI 3.4–13.2; p < 0.0001). Conclusion This study showed that the GSTT1-null alone or in interaction with GSTM1-present or GSTM1-null was associated with a higher risk of hypertension. Moreover, the GSTM1-null seems to be associated with the age of onset of hypertension.
Essential hypertension (EH) results from a complex interaction between environmental factors and an individual's genetic background. To assess the relationship between polymorphisms in GSTM1 and GSTT1 and the risk of EH. A multiplex-PCR was used to identify the genotypic profiles of GSTM1 and GSTT1 in 160 patients and 210 controls. The frequency of GSTM1-null genotype was higher in patients younger than 61 years when compared to those over 61 years. Interestingly, GSTT1-null was significantly associated with the risk of EH (OR 4; 95% CI 2.6-6.3; p < 0.0001). While GSTM1-null showed no trend (OR 0.7; 95% CI 0.5-1.1, p = 0.12). Individuals carrying the combined GSTT1-null/GSTM1-null were 2.4 times more at risk for hypertension compared to those harbouring the combined GSTT1-present/GSTM1-present genotype (OR 2.4; 95% CI 1.3-4.4; p = 0.005). Additionally, the presence of the combined GSTT1-null/GSTM1-present was associated with an increased risk of EH compared to GSTT1-present/GSTM1-present carriers (OR 6.75; 95% CI 3.4-13.2; p < 0.0001). This study showed that the GSTT1-null alone or in interaction with GSTM1-present or GSTM1-null was associated with a higher risk of hypertension. Moreover, the GSTM1-null seems to be associated with the age of onset of hypertension.
Essential hypertension (EH) results from a complex interaction between environmental factors and an individual's genetic background.BACKGROUNDEssential hypertension (EH) results from a complex interaction between environmental factors and an individual's genetic background.To assess the relationship between polymorphisms in GSTM1 and GSTT1 and the risk of EH.AIMTo assess the relationship between polymorphisms in GSTM1 and GSTT1 and the risk of EH.A multiplex-PCR was used to identify the genotypic profiles of GSTM1 and GSTT1 in 160 patients and 210 controls.SUBJECTS AND METHODSA multiplex-PCR was used to identify the genotypic profiles of GSTM1 and GSTT1 in 160 patients and 210 controls.The frequency of GSTM1-null genotype was higher in patients younger than 61 years when compared to those over 61 years. Interestingly, GSTT1-null was significantly associated with the risk of EH (OR 4; 95% CI 2.6-6.3; p < 0.0001). While GSTM1-null showed no trend (OR 0.7; 95% CI 0.5-1.1, p = 0.12). Individuals carrying the combined GSTT1-null/GSTM1-null were 2.4 times more at risk for hypertension compared to those harbouring the combined GSTT1-present/GSTM1-present genotype (OR 2.4; 95% CI 1.3-4.4; p = 0.005). Additionally, the presence of the combined GSTT1-null/GSTM1-present was associated with an increased risk of EH compared to GSTT1-present/GSTM1-present carriers (OR 6.75; 95% CI 3.4-13.2; p < 0.0001).RESULTSThe frequency of GSTM1-null genotype was higher in patients younger than 61 years when compared to those over 61 years. Interestingly, GSTT1-null was significantly associated with the risk of EH (OR 4; 95% CI 2.6-6.3; p < 0.0001). While GSTM1-null showed no trend (OR 0.7; 95% CI 0.5-1.1, p = 0.12). Individuals carrying the combined GSTT1-null/GSTM1-null were 2.4 times more at risk for hypertension compared to those harbouring the combined GSTT1-present/GSTM1-present genotype (OR 2.4; 95% CI 1.3-4.4; p = 0.005). Additionally, the presence of the combined GSTT1-null/GSTM1-present was associated with an increased risk of EH compared to GSTT1-present/GSTM1-present carriers (OR 6.75; 95% CI 3.4-13.2; p < 0.0001).This study showed that the GSTT1-null alone or in interaction with GSTM1-present or GSTM1-null was associated with a higher risk of hypertension. Moreover, the GSTM1-null seems to be associated with the age of onset of hypertension.CONCLUSIONThis study showed that the GSTT1-null alone or in interaction with GSTM1-present or GSTM1-null was associated with a higher risk of hypertension. Moreover, the GSTM1-null seems to be associated with the age of onset of hypertension.
Essential hypertension (EH) results from a complex interaction between environmental factors and an individual's genetic background. To assess the relationship between polymorphisms in and and the risk of EH. A multiplex-PCR was used to identify the genotypic profiles of and in 160 patients and 210 controls. The frequency of -null genotype was higher in patients younger than 61 years when compared to those over 61 years. Interestingly, -null was significantly associated with the risk of EH (OR 4; 95% CI 2.6-6.3;  < 0.0001). While -null showed no trend (OR 0.7; 95% CI 0.5-1.1,  = 0.12). Individuals carrying the combined -null/ -null were 2.4 times more at risk for hypertension compared to those harbouring the combined -present/ -present genotype (OR 2.4; 95% CI 1.3-4.4;  = 0.005). Additionally, the presence of the combined -null/ -present was associated with an increased risk of EH compared to -present/ -present carriers (OR 6.75; 95% CI 3.4-13.2;  < 0.0001). This study showed that the -null alone or in interaction with -present or -null was associated with a higher risk of hypertension. Moreover, the -null seems to be associated with the age of onset of hypertension.
Author Nassereddine, Sanaa
Habbal, Rachida
Kaltoum, Ait Boujmia Oum
Kassogue, Yaya
Majda, Haraka
Rhizlane, Abou Elfath
Dehbi, Hind
Farah, Korchi
Nadifi, Sellama
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Snippet Essential hypertension (EH) results from a complex interaction between environmental factors and an individual's genetic background. To assess the relationship...
Essential hypertension (EH) results from a complex interaction between environmental factors and an individual's genetic background.BACKGROUNDEssential...
Background Essential hypertension (EH) results from a complex interaction between environmental factors and an individual’s genetic background. Aim To assess...
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SubjectTerms Case-Control Studies
essential hypertension
Essential Hypertension - genetics
Genetic Predisposition to Disease
Genotype
Glutathione S-transferase
Glutathione Transferase - genetics
GSTM1
GSTT1
Humans
Middle Aged
Morocco
Polymorphism, Genetic
Risk Factors
Title Analysis of the influence of glutathione S-transferase (GSTM1 and GSTT1) genes on the risk of essential hypertension
URI https://www.tandfonline.com/doi/abs/10.1080/03014460.2022.2039291
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