Increased non-protein bound iron in Down syndrome: contribution to lipid peroxidation and cognitive decline

• Published in: Free radical research Vol. 50; no. 12; pp. 1422 - 1431
• Main Authors: Manna, Caterina, Officioso, Arbace, Trojsi, Francesca, Tedeschi, Gioacchino, Leoncini, Silvia, Signorini, Cinzia, Ciccoli, Lucia, De Felice, Claudio
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.12.2016
• Subjects: Alzheimer's disease; cognitive decline; Cognitive Dysfunction - genetics; Cognitive Dysfunction - metabolism; Down syndrome; Down Syndrome - complications; Humans; iron; Iron - metabolism; lipid peroxidation; Lipid Peroxidation - genetics; Oxidative Stress; iron; Down syndrome; Alzheimer’s disease; cognitive decline; lipid peroxidation

Down syndrome (DS, trisomy 21) is the leading cause of chromosomal-related intellectual disability. At an early age, adults with DS develop with the neuropathological hallmarks of Alzheimer's disease, associated with a chronic oxidative stress. To investigate if non-protein bound iron (NPBI) ca...