Reduced Langerhans' Cell Ia Antigen and ATPase Activity in Patients with the Acquired Immunodeficiency Syndrome

• Published in: The New England journal of medicine Vol. 310; no. 20; pp. 1279 - 1282
• Main Authors: Belsito, Donald V, Sanchez, Miguel R, Baer, Rudolf L, Valentine, Fred, Thorbecke, G. Jeanette
• Format: Journal Article
• Language: English
• Published: Boston, MA Massachusetts Medical Society 17.05.1984
• Subjects: Acquired immune deficiency syndrome; Acquired Immunodeficiency Syndrome - enzymology; Acquired Immunodeficiency Syndrome - immunology; Adenosine triphosphatase; Adenosine Triphosphatases - metabolism; Adolescent; Adult; AIDS; AIDS-related complex; AIDS/HIV; Antigen presentation; Antigen-presenting cells; Biological and medical sciences; Biopsy; Cell Count; Circumcision; Enumeration; Female; Gene expression; Histocompatibility Antigens Class II - analysis; Humans; Immunodeficiencies. Immunoglobulinopathies; Immunodeficiency; Immunopathology; Infections; Kaposi's sarcoma; La antigen; Langerhans Cells - enzymology; Langerhans Cells - immunology; Light; Male; Medical sciences; Middle Aged; Patients; Skin; Stains & staining; Women; Human; Infection; Immunopathology; Kaposi sarcoma; Skin disease; Enzymatic activity; Langerhans cell; ATPase; AIDS; Skin; Ia-System

We investigated the possible role of a defect in antigen-presenting cells in the acquired immunodeficiency syndrome (AIDS), by enumeration of Langerhans' cells, the epidermal antigen-presenting cells. These cells were stained for the characteristic markers, surface la antigen and surface ATPase...