Vitamin B-12–fortified toothpaste improves vitamin status in vegans: a 12-wk randomized placebo-controlled study

• Published in: The American journal of clinical nutrition Vol. 105; no. 3; pp. 618 - 625
• Main Authors: Siebert, Anne-Kathrin, Obeid, Rima, Weder, Stine, Awwad, Hussain M, Sputtek, Andreas, Geisel, Juergen, Keller, Markus
• Format: Journal Article
• Language: English
• Published: United States American Society for Clinical Nutrition, Inc 01.03.2017
• Subjects: Adult; Biomarkers - blood; blood serum; Clinical trials; Dental care; Diet; Double-Blind Method; Female; homocysteine; Homocysteine - blood; Humans; Male; methylmalonic acid; Methylmalonic Acid - blood; mouth; Mouth Mucosa - metabolism; Nutritional Status; placebos; toothpaste; Toothpastes; Transcobalamins - metabolism; vegan diet; Vegans; Vegetables; Vitamin B; Vitamin B 12 - blood; Vitamin B 12 - pharmacokinetics; Vitamin B 12 - pharmacology; Vitamin B 12 Deficiency - blood; Vitamin B 12 Deficiency - prevention & control; Vitamin B Complex - blood; Vitamin B Complex - pharmacokinetics; Vitamin B Complex - pharmacology; vitamin B12; vitamin status; Young Adult; holotranscobalamin; methylmalonic acid; supplementation; vitamin B-12; deficiency; vegans

The oral application of vitamin B-12 may prevent its deficiency if the vitamin is absorbed via the mucosal barrier. We studied the effect of the use of a vitamin B-12-fortified toothpaste on vitamin-status markers in vegans and assessed the efficiency of markers in the identification of vitamin-augm...