Drug metabolism by flavin-containing monooxygenases of human and mouse

• Published in: Expert opinion on drug metabolism & toxicology Vol. 13; no. 2; p. 167
• Main Authors: Phillips, Ian R, Shephard, Elizabeth A
• Format: Journal Article
• Language: English
• Published: England 01.02.2017
• Subjects: Animals; Cytochrome P-450 Enzyme System - metabolism; Genetic Variation; Humans; Mice; Models, Animal; Oxygenases - genetics; Oxygenases - metabolism; Pharmaceutical Preparations - metabolism; Species Specificity; Animal model; mouse; drug metabolism; flavin-containing monooxygenase; FMO; CYP; cytochrome P450; genetic variant; human; knockout mouse
• ISSN: 1744-7607
• DOI: 10.1080/17425255.2017.1239718

Flavin-containing monooxygenases (FMOs) play an important role in drug metabolism. Areas covered: We focus on the role of FMOs in the metabolism of drugs in human and mouse. We describe FMO genes and proteins of human and mouse; the catalytic mechanism of FMOs and their significance for drug metabol...