Roles of Superoxide Radical Anion in Signal Transduction Mediated by Reversible Regulation of Protein-tyrosine Phosphatase 1B

• Published in: The Journal of biological chemistry Vol. 274; no. 49; pp. 34543 - 34546
• Main Authors: Barrett, W C, DeGnore, J P, Keng, Y F, Zhang, Z Y, Yim, M B, Chock, P B
• Format: Journal Article
• Language: English
• Published: United States American Society for Biochemistry and Molecular Biology 03.12.1999
• Subjects: Anions - metabolism; Carrier Proteins - metabolism; Catalase - pharmacology; Chromatography, Liquid; Enzyme Activation - drug effects; Enzyme Activation - physiology; Humans; Hydrogen Peroxide - metabolism; Kinetics; Mass Spectrometry; Membrane Proteins - metabolism; Oxidation-Reduction; Protein Tyrosine Phosphatase, Non-Receptor Type 1; Protein Tyrosine Phosphatases; Reactive Oxygen Species - metabolism; Signal Transduction; Superoxides - metabolism; Time Factors; Tumor Cells, Cultured; Xanthine - pharmacology

Growth factors induce intracellular production of reactive oxygen species in non-phagocytic cells and elevation of their phosphorylated protein tyrosine level. The latter can be achieved by activating protein-tyrosine kinases and/or inactivating protein-tyrosine phosphatases (PTPs). A highly abundan...