Multifunctional lipid-coated calcium phosphate nanoplatforms for complete inhibition of large triple negative breast cancer via targeted combined therapy

• Published in: Biomaterials Vol. 216; p. 119232
• Main Authors: Tang, Jie, Li, Bei, Howard, Christopher B., Mahler, Stephen M., Thurecht, Kristofer J., Wu, Yilun, Huang, Leaf, Xu, Zhi Ping
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.09.2019
• Subjects: Bispecific target delivery; Large breast tumor model; Lipid-coated calcium phosphate nanoparticles; Photothermal therapy; RNAi therapy; Photothermal therapy; Large breast tumor model; Lipid-coated calcium phosphate nanoparticles; RNAi therapy; Bispecific target delivery

Combined and targeted therapy have been extensively employed to achieve more effective elimination of tumor tissues. In this study, biocompatible multifunctional lipid-coated calcium phosphate nanoparticles (LCP NPs) were designed and constructed as an efficient targeted delivery system for combined...