Kappa Opioid Receptor-mediated Modulation of Social Responding in Adolescent Rats and in Rats Prenatally Exposed to Valproic Acid

• Published in: Neuroscience Vol. 444; pp. 9 - 18
• Main Authors: Hughes, Edel M., Thornton, Aoife M., Kerr, Daniel M, Smith, Karen, Sanchez, Connie, Kelly, John P., Finn, David P., Roche, Michelle
• Format: Journal Article
• Language: English
• Published: United States Elsevier Ltd 15.09.2020
• Subjects: Amygdala; Animals; Anticonvulsants - toxicity; autism; cfos; Disease Models, Animal; Dynorphin; Female; Male; opioid; Pregnancy; Prenatal Exposure Delayed Effects; Rats; Receptors, Opioid, kappa; Social Behavior; social behaviour; valporate; Valproic Acid - toxicity; penk; VPA; oprk1; opioid; social behaviour; s.c; cfos; IEG; KOP; valporate; autism; Dynorphin; DYN; DIPPA; pdyn

•KOP antagonism enhances sociability in adolescent rats.•KOP agonism and antagonism impairs social novelty preference in adolescent rats.•KOP agonism or antagonism does not alter sociability or social novelty preference in VPA-exposed rats.•VPA-exposed rats exhibit increased expression of oprk1 and...