Increased Oxidative Stress in Asthma—Relation to Inflammatory Blood and Lung Biomarkers and Airway Remodeling Indices

• Published in: Biomedicines Vol. 10; no. 7; p. 1499
• Main Authors: Bazan-Socha, Stanisława, Wójcik, Krzysztof, Olchawa, Magdalena, Sarna, Tadeusz, Pięta, Jakub, Jakieła, Bogdan, Soja, Jerzy, Okoń, Krzysztof, Zarychta, Jacek, Zaręba, Lech, Stojak, Michał, Potaczek, Daniel P., Bazan, Jan G., Celińska-Lowenhoff, Magdalena
• Format: Journal Article
• Language: English
• Published: Switzerland MDPI AG 24.06.2022; MDPI
• Subjects: airway remodeling; Asthma; Atherosclerosis; Biomarkers; Blood; Bronchus; C-reactive protein; CBA assay; Citrulline; Computed tomography; Coumarin; Disease control; Histones; Inflammation; Interleukin 12; Interleukin 6; Laboratories; Lavage; Leukocytes (neutrophilic); Lung diseases; Lungs; Oxidative stress; Pathogenesis; Peripheral blood; Plasma; Proteins; Reactive oxygen species; Respiratory function; Respiratory tract; Respiratory tract diseases; Spirometry; Tomography; United States > US; Japan; Germany; CBA assay; asthma; oxidative stress; airway remodeling

Airway inflammation in asthma is related to increased reactive oxygen species generation, potentially leading to tissue injury and subsequent airway remodeling. We evaluated oxidative stress in peripheral blood from asthmatic subjects (n = 74) and matched controls (n = 65), using recently developed...