Divergent DNA methylation patterns and gene expression in MYC and CDKN2B in canine transmissible venereal tumors

• Published in: Veterinary World Vol. 17; no. 7; pp. 1581 - 1590
• Main Authors: Keopaseuth, Soukkangna, Pringproa, Kidsadagon, Patchanee, Prapas, Setthawongsin, Chanokchon, Techangamsuwan, Somporn, Chuammitri, Phongsakorn
• Format: Journal Article
• Language: English
• Published: India Veterinary World 01.07.2024
• Subjects: canine transmissible venereal tumor; cdkn2b; dna methylation; myc; oncogene; tumor suppressor gene; DNA methylation; CDKN2B; canine transmissible venereal tumor; oncogene; MYC; tumor suppressor gene

Background and Aim: Canine transmissible venereal tumor (CTVT), a unique transmissible cancer in dogs, affects the external genitalia and potentially spreads to other parts of the body. While somatic mutations in oncogenic and tumor-suppressing genes are linked to CTVT development, the impact of DNA...