METTL3-m6A-Rubicon axis inhibits autophagy in nonalcoholic fatty liver disease

• Published in: Molecular therapy Vol. 30; no. 2; pp. 932 - 946
• Main Authors: Peng, Zishan, Gong, Yingying, Wang, Xuejie, He, Weiman, Wu, Liting, Zhang, Luyao, Xiong, Li, Huang, Yanrui, Su, Lei, Shi, Peijie, Cao, Xiaopei, Liu, Rengyun, Li, Yanbing, Xiao, Haipeng
• Format: Journal Article
• Language: English
• Published: Elsevier Inc 02.02.2022; American Society of Gene & Cell Therapy
• Subjects: autophagy; m6A modification; METTL3; NAFLD; Original; YTHDF1; m6A modification; YTHDF1; NAFLD; autophagy; METTL3

N6-methyladenosine (m6A) mRNA modification plays critical roles in various biological events and is involved in multiple complex diseases. However, the role of m6A modification in autophagy in nonalcoholic fatty liver disease (NAFLD) remains largely unknown. Here, we report that m6A modification was...