Feline mammary carcinoma-derived extracellular vesicle promotes liver metastasis via sphingosine kinase-1-mediated premetastatic niche formation

• Published in: Laboratory animal research Vol. 39; no. 1; pp. 27 - 15
• Main Authors: Chang, Yi-Chih, Liu, Hao-Ping, Chuang, Hsiao-Li, Liao, Jiunn-Wang, Kao, Pei-Ling, Chan, Hsun-Lung, Chen, Ter-Hsin, Wang, Yu-Chih
• Format: Journal Article
• Language: English
• Published: London BioMed Central 09.11.2023; BMC; 한국실험동물학회
• Subjects: Extracellular vesicle; Feline mammary carcinoma; Hepatic stellate cell; Pre-metastatic niche; Sphingosine kinase-1; 수의학

Feline mammary carcinoma (FMC) is one of the most prevalent malignancies of female cats. FMC is highly metastatic and thus leads to poor disease outcomes. Among all metastases, liver metastasis occurs in about 25% of FMC patients. However, the mechanism underlying hepatic metastasis of FMC remains l...