HREM, RNAseq and Cell Cycle Analyses Reveal the Role of the G2/M-Regulatory Protein, WEE1, on the Survivability of Chicken Embryos during Diapause
Avian blastoderm can enter into diapause when kept at low temperatures and successfully resume development (SRD) when re-incubated in body temperature. These abilities, which are largely affected by the temperature and duration of the diapause, are poorly understood at the cellular and molecular lev...
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Published in | Biomedicines Vol. 10; no. 4; p. 779 |
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Language | English |
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Abstract | Avian blastoderm can enter into diapause when kept at low temperatures and successfully resume development (SRD) when re-incubated in body temperature. These abilities, which are largely affected by the temperature and duration of the diapause, are poorly understood at the cellular and molecular level. To determine how temperature affects embryonic morphology during diapause, high-resolution episcopic microscopy (HREM) analysis was utilized. While blastoderms diapausing at 12 °C for 28 days presented typical cytoarchitecture, similar to non-diapaused embryos, at 18 °C, much thicker blastoderms with higher cell number were observed. RNAseq was conducted to discover the genes underlying these phenotypes, revealing differentially expressed cell cycle regulatory genes. Among them,
, a negative regulator of G2/M transition, was highly expressed at 12 °C compared to 18 °C. This finding suggested that cells at 12 °C are arrested at the G2/M phase, as supported by bromodeoxyuridine incorporation (BrdU) assay and phospho-histone H3 (pH 3) immunostaining. Inhibition of WEE1 during diapause at 12 °C resulted in cell cycle progression beyond the G2/M and augmented tissue volume, resembling the morphology of 18 °C-diapaused embryos. These findings suggest that diapause at low temperatures leads to
upregulation, which arrests the cell cycle at the G2/M phase, promoting the perseverance of embryonic cytoarchitecture and future SRD. In contrast,
is not upregulated during diapause at higher temperature, leading to continuous proliferation and maladaptive morphology associated with poor survivability. Combining HREM-based analysis with RNAseq and molecular manipulations, we present a novel mechanism that regulates the ability of diapaused avian embryos to maintain their cytoarchitecture via cell cycle arrest, which enables their SRD. |
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AbstractList | Avian blastoderm can enter into diapause when kept at low temperatures and successfully resume development (SRD) when re-incubated in body temperature. These abilities, which are largely affected by the temperature and duration of the diapause, are poorly understood at the cellular and molecular level. To determine how temperature affects embryonic morphology during diapause, high-resolution episcopic microscopy (HREM) analysis was utilized. While blastoderms diapausing at 12 °C for 28 days presented typical cytoarchitecture, similar to non-diapaused embryos, at 18 °C, much thicker blastoderms with higher cell number were observed. RNAseq was conducted to discover the genes underlying these phenotypes, revealing differentially expressed cell cycle regulatory genes. Among them, WEE1, a negative regulator of G2/M transition, was highly expressed at 12 °C compared to 18 °C. This finding suggested that cells at 12 °C are arrested at the G2/M phase, as supported by bromodeoxyuridine incorporation (BrdU) assay and phospho-histone H3 (pH 3) immunostaining. Inhibition of WEE1 during diapause at 12 °C resulted in cell cycle progression beyond the G2/M and augmented tissue volume, resembling the morphology of 18 °C-diapaused embryos. These findings suggest that diapause at low temperatures leads to WEE1 upregulation, which arrests the cell cycle at the G2/M phase, promoting the perseverance of embryonic cytoarchitecture and future SRD. In contrast, WEE1 is not upregulated during diapause at higher temperature, leading to continuous proliferation and maladaptive morphology associated with poor survivability. Combining HREM-based analysis with RNAseq and molecular manipulations, we present a novel mechanism that regulates the ability of diapaused avian embryos to maintain their cytoarchitecture via cell cycle arrest, which enables their SRD. Avian blastoderm can enter into diapause when kept at low temperatures and successfully resume development (SRD) when re-incubated in body temperature. These abilities, which are largely affected by the temperature and duration of the diapause, are poorly understood at the cellular and molecular level. To determine how temperature affects embryonic morphology during diapause, high-resolution episcopic microscopy (HREM) analysis was utilized. While blastoderms diapausing at 12 °C for 28 days presented typical cytoarchitecture, similar to non-diapaused embryos, at 18 °C, much thicker blastoderms with higher cell number were observed. RNAseq was conducted to discover the genes underlying these phenotypes, revealing differentially expressed cell cycle regulatory genes. Among them, WEE1, a negative regulator of G2/M transition, was highly expressed at 12 °C compared to 18 °C. This finding suggested that cells at 12 °C are arrested at the G2/M phase, as supported by bromodeoxyuridine incorporation (BrdU) assay and phospho-histone H3 (pH 3) immunostaining. Inhibition of WEE1 during diapause at 12 °C resulted in cell cycle progression beyond the G2/M and augmented tissue volume, resembling the morphology of 18 °C-diapaused embryos. These findings suggest that diapause at low temperatures leads to WEE1 upregulation, which arrests the cell cycle at the G2/M phase, promoting the perseverance of embryonic cytoarchitecture and future SRD. In contrast, WEE1 is not upregulated during diapause at higher temperature, leading to continuous proliferation and maladaptive morphology associated with poor survivability. Combining HREM-based analysis with RNAseq and molecular manipulations, we present a novel mechanism that regulates the ability of diapaused avian embryos to maintain their cytoarchitecture via cell cycle arrest, which enables their SRD.Avian blastoderm can enter into diapause when kept at low temperatures and successfully resume development (SRD) when re-incubated in body temperature. These abilities, which are largely affected by the temperature and duration of the diapause, are poorly understood at the cellular and molecular level. To determine how temperature affects embryonic morphology during diapause, high-resolution episcopic microscopy (HREM) analysis was utilized. While blastoderms diapausing at 12 °C for 28 days presented typical cytoarchitecture, similar to non-diapaused embryos, at 18 °C, much thicker blastoderms with higher cell number were observed. RNAseq was conducted to discover the genes underlying these phenotypes, revealing differentially expressed cell cycle regulatory genes. Among them, WEE1, a negative regulator of G2/M transition, was highly expressed at 12 °C compared to 18 °C. This finding suggested that cells at 12 °C are arrested at the G2/M phase, as supported by bromodeoxyuridine incorporation (BrdU) assay and phospho-histone H3 (pH 3) immunostaining. Inhibition of WEE1 during diapause at 12 °C resulted in cell cycle progression beyond the G2/M and augmented tissue volume, resembling the morphology of 18 °C-diapaused embryos. These findings suggest that diapause at low temperatures leads to WEE1 upregulation, which arrests the cell cycle at the G2/M phase, promoting the perseverance of embryonic cytoarchitecture and future SRD. In contrast, WEE1 is not upregulated during diapause at higher temperature, leading to continuous proliferation and maladaptive morphology associated with poor survivability. Combining HREM-based analysis with RNAseq and molecular manipulations, we present a novel mechanism that regulates the ability of diapaused avian embryos to maintain their cytoarchitecture via cell cycle arrest, which enables their SRD. Avian blastoderm can enter into diapause when kept at low temperatures and successfully resume development (SRD) when re-incubated in body temperature. These abilities, which are largely affected by the temperature and duration of the diapause, are poorly understood at the cellular and molecular level. To determine how temperature affects embryonic morphology during diapause, high-resolution episcopic microscopy (HREM) analysis was utilized. While blastoderms diapausing at 12 °C for 28 days presented typical cytoarchitecture, similar to non-diapaused embryos, at 18 °C, much thicker blastoderms with higher cell number were observed. RNAseq was conducted to discover the genes underlying these phenotypes, revealing differentially expressed cell cycle regulatory genes. Among them, WEE1 , a negative regulator of G2/M transition, was highly expressed at 12 °C compared to 18 °C. This finding suggested that cells at 12 °C are arrested at the G2/M phase, as supported by bromodeoxyuridine incorporation (BrdU) assay and phospho-histone H3 (pH 3) immunostaining. Inhibition of WEE1 during diapause at 12 °C resulted in cell cycle progression beyond the G2/M and augmented tissue volume, resembling the morphology of 18 °C-diapaused embryos. These findings suggest that diapause at low temperatures leads to WEE1 upregulation, which arrests the cell cycle at the G2/M phase, promoting the perseverance of embryonic cytoarchitecture and future SRD. In contrast, WEE1 is not upregulated during diapause at higher temperature, leading to continuous proliferation and maladaptive morphology associated with poor survivability. Combining HREM-based analysis with RNAseq and molecular manipulations, we present a novel mechanism that regulates the ability of diapaused avian embryos to maintain their cytoarchitecture via cell cycle arrest, which enables their SRD. Avian blastoderm can enter into diapause when kept at low temperatures and successfully resume development (SRD) when re-incubated in body temperature. These abilities, which are largely affected by the temperature and duration of the diapause, are poorly understood at the cellular and molecular level. To determine how temperature affects embryonic morphology during diapause, high-resolution episcopic microscopy (HREM) analysis was utilized. While blastoderms diapausing at 12 °C for 28 days presented typical cytoarchitecture, similar to non-diapaused embryos, at 18 °C, much thicker blastoderms with higher cell number were observed. RNAseq was conducted to discover the genes underlying these phenotypes, revealing differentially expressed cell cycle regulatory genes. Among them, , a negative regulator of G2/M transition, was highly expressed at 12 °C compared to 18 °C. This finding suggested that cells at 12 °C are arrested at the G2/M phase, as supported by bromodeoxyuridine incorporation (BrdU) assay and phospho-histone H3 (pH 3) immunostaining. Inhibition of WEE1 during diapause at 12 °C resulted in cell cycle progression beyond the G2/M and augmented tissue volume, resembling the morphology of 18 °C-diapaused embryos. These findings suggest that diapause at low temperatures leads to upregulation, which arrests the cell cycle at the G2/M phase, promoting the perseverance of embryonic cytoarchitecture and future SRD. In contrast, is not upregulated during diapause at higher temperature, leading to continuous proliferation and maladaptive morphology associated with poor survivability. Combining HREM-based analysis with RNAseq and molecular manipulations, we present a novel mechanism that regulates the ability of diapaused avian embryos to maintain their cytoarchitecture via cell cycle arrest, which enables their SRD. |
Author | Sela-Donenfeld, Dalit Pokhrel, Narayan Cinnamon, Yuval Genin, Olga |
AuthorAffiliation | 1 Agriculture Research Organization, The Volcani Center, Department of Poultry and Aquaculture Science, Bet Dagan 50250, Israel; narayan.pokhrel@mail.huji.ac.il (N.P.); olga.genin5654@gmail.com (O.G.) 2 The Robert H. Smith Faculty of Agriculture, Food and Environment, Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot 7610001, Israel |
AuthorAffiliation_xml | – name: 2 The Robert H. Smith Faculty of Agriculture, Food and Environment, Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot 7610001, Israel – name: 1 Agriculture Research Organization, The Volcani Center, Department of Poultry and Aquaculture Science, Bet Dagan 50250, Israel; narayan.pokhrel@mail.huji.ac.il (N.P.); olga.genin5654@gmail.com (O.G.) |
Author_xml | – sequence: 1 givenname: Narayan orcidid: 0000-0001-9605-0253 surname: Pokhrel fullname: Pokhrel, Narayan organization: The Robert H. Smith Faculty of Agriculture, Food and Environment, Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot 7610001, Israel – sequence: 2 givenname: Olga surname: Genin fullname: Genin, Olga organization: Agriculture Research Organization, The Volcani Center, Department of Poultry and Aquaculture Science, Bet Dagan 50250, Israel – sequence: 3 givenname: Dalit orcidid: 0000-0001-7498-061X surname: Sela-Donenfeld fullname: Sela-Donenfeld, Dalit organization: The Robert H. Smith Faculty of Agriculture, Food and Environment, Koret School of Veterinary Medicine, The Hebrew University of Jerusalem, Rehovot 7610001, Israel – sequence: 4 givenname: Yuval orcidid: 0000-0002-6234-8219 surname: Cinnamon fullname: Cinnamon, Yuval organization: Agriculture Research Organization, The Volcani Center, Department of Poultry and Aquaculture Science, Bet Dagan 50250, Israel |
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CitedBy_id | crossref_primary_10_3390_biomedicines10051123 crossref_primary_10_3389_fphys_2022_960061 |
Cites_doi | 10.1101/pdb.prot086199 10.1016/j.ydbio.2006.10.014 10.1038/nature09373 10.1073/pnas.1905722116 10.3390/ijms221910689 10.1002/ecy.2230 10.1093/nar/gkz401 10.1007/s00412-018-0660-2 10.1016/j.brainresprot.2004.04.001 10.1242/dev.054387 10.1158/0008-5472.CAN-18-0569 10.1101/gad.14.12.1439 10.1016/0022-1910(72)90238-7 10.7150/ijbs.2.161 10.1038/onc.2014.239 10.1128/AEM.02845-13 10.1111/gcb.14837 10.1242/jcs.226969 10.1017/S1464793101005784 10.1098/rsob.190299 10.3382/ps/pex393 10.1186/s13059-014-0550-8 10.1017/erm.2020.3 10.1016/j.mod.2020.103624 10.1083/jcb.201612147 10.1038/srep07825 10.1158/1535-7163.MCT-09-0463 10.1038/nrm2832 10.1371/journal.pone.0039723 10.1038/ncb3452 10.1007/s00429-005-0073-x 10.1016/j.coph.2005.04.009 10.1016/0012-1606(76)90178-0 10.1101/cshperspect.a012716 10.1038/s41598-019-42961-w 10.1186/s13227-019-0142-5 10.1101/gad.12.15.2245 10.1016/j.anireprosci.2008.09.005 10.3382/ps/pex242 10.1038/s41580-021-00404-3 10.1117/12.763578 10.1016/j.cell.2013.05.039 10.1093/nar/gkv468 10.1038/s41598-019-51959-3 10.3389/fphar.2018.01041 10.3390/biom11101523 10.1007/978-94-007-4186-7 10.1096/fj.201601051RR 10.1016/j.envint.2019.03.064 10.1158/1535-7163.MCT-11-0529 10.1002/mc.22681 10.1016/j.ydbio.2010.06.001 10.1242/dev.116.3.819 10.1080/11250008409439457 10.1096/fj.201901217RR 10.4161/cc.26062 10.1006/dbio.1996.0023 10.1371/journal.pone.0126230 10.2307/3545073 10.1038/343273a0 10.1111/j.1365-2656.2012.01961.x 10.1038/ncomms5487 10.1128/MCB.16.6.2570 10.1152/physrev.00020.2018 10.1038/s41598-019-42562-7 10.1016/0092-8674(93)80048-J 10.1016/j.psj.2021.101227 10.1007/s00018-002-8510-y 10.1186/s12859-017-1934-z 10.1242/dev.00971 10.1038/s41598-018-32203-w 10.1038/s41598-020-66018-5 10.1016/j.fsi.2017.03.003 10.1093/bioinformatics/btm091 10.1038/nrm3629 10.1089/scd.2009.0475 10.1073/pnas.2009864117 10.1089/adt.2011.0397 10.1016/j.tips.2016.06.006 10.1371/journal.pgen.1005787 10.3892/ol.2017.6584 10.1136/ijgc-2020-001277 10.1098/rspb.2012.0100 10.1016/j.pharmthera.2017.02.008 10.3748/wjg.v10.i2.155 10.1093/biolre/ioz017 10.1016/j.aanat.2014.10.012 10.1242/dev.070730 10.1038/s41598-017-18389-5 10.1002/pro.3715 10.1038/nmeth.2089 10.1093/ps/86.5.1020 10.4161/cbt.9.7.11115 10.1111/j.1469-7580.2009.01168.x 10.1016/B978-0-12-380888-2.00003-0 10.1093/beheco/arm026 10.3390/cancers13040795 |
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Keywords | chicken embryonic diapause chicken embryonic blastoderm WEE1 cell cycle G2/M transition mitosis RNAseq high-resolution episcopic microscopy (HREM) |
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References | Morison (ref_72) 2020; 26 Ma (ref_12) 2017; 56 Feng (ref_59) 2014; 5 Ishizaki (ref_93) 1972; 18 Kamemizu (ref_69) 2019; 100 Koressaar (ref_38) 2007; 23 Schneider (ref_31) 2012; 9 Shipley (ref_105) 2020; 117 Taborsky (ref_86) 2007; 18 ref_95 Cassill (ref_88) 2019; 9 Goldberg (ref_89) 2015; 5 Fasenko (ref_2) 2007; 86 Dieser (ref_73) 2013; 79 Yam (ref_14) 2002; 59 Matheson (ref_68) 2016; 37 Rafferty (ref_94) 2012; 279 Nayan (ref_99) 2011; 2011 Wan (ref_34) 2017; 7 Dolfi (ref_70) 2019; 10 Varner (ref_64) 2010; 137 Debby (ref_66) 1992; 116 Strauss (ref_23) 2018; 217 Collins (ref_18) 2005; 5 Geyer (ref_67) 2015; 197 Ko (ref_9) 2017; 31 ref_29 Zhang (ref_92) 2019; 9 ref_26 Pokhrel (ref_4) 2021; 100 Heald (ref_104) 1993; 74 Bertoli (ref_13) 2013; 14 ref_79 Peretz (ref_40) 2018; 8 ref_77 Baudoin (ref_44) 2018; 127 Zou (ref_78) 2013; 5 Hanael (ref_41) 2020; 34 Ha (ref_56) 2020; 10 Tominaga (ref_24) 2006; 2 Cheng (ref_74) 2017; 64 Kohl (ref_28) 2019; 129 Weijer (ref_60) 2020; 163 Morrongiello (ref_84) 2012; 81 Stern (ref_6) 1990; 343 Christians (ref_85) 2002; 77 Yang (ref_76) 2004; 10 Love (ref_33) 2014; 15 Liao (ref_32) 2019; 47 Lee (ref_57) 2019; 9 Stern (ref_1) 2012; 139 Qiu (ref_75) 2011; 154 Pokhrel (ref_27) 2017; 96 Berrigan (ref_83) 1991; 60 Lee (ref_65) 2020; 10 Vassilopoulos (ref_25) 2015; 34 Smith (ref_80) 2020; 22 Pai (ref_103) 2019; 132 Carruthers (ref_101) 2018; 78 Calcinotto (ref_96) 2019; 99 Zhang (ref_54) 2017; 14 Yi (ref_35) 1999; 19 Geyer (ref_52) 2017; 125 Hirai (ref_46) 2010; 9 Petrosius (ref_20) 2020; 819 Ngoi (ref_102) 2020; 30 Kanehisa (ref_36) 2019; 28 ref_61 Takai (ref_21) 2000; 14 Murakami (ref_71) 2004; 131 Hirai (ref_22) 2009; 8 Kreahling (ref_47) 2012; 11 Matthews (ref_53) 2022; 23 Huang (ref_15) 2013; 8 Do (ref_17) 2013; 12 Pokhrel (ref_3) 2018; 97 Weninger (ref_51) 2006; 211 Zegerman (ref_19) 2010; 467 ref_62 Weisinger (ref_50) 2010; 344 Walczak (ref_43) 2010; 11 Daniel (ref_49) 2004; 13 Lasorella (ref_11) 1996; 16 Kochav (ref_5) 1976; 49 ref_30 Xie (ref_98) 2011; 20 Dyson (ref_10) 1998; 12 Slattery (ref_42) 2012; 10 Metsalu (ref_37) 2015; 43 Mazzini (ref_91) 1984; 51 Ugryumova (ref_63) 2008; 6847 Denton (ref_58) 2015; 2015 Mansour (ref_90) 2009; 114 Gerhart (ref_8) 1996; 173 Hustedt (ref_81) 2017; 19 ref_45 Lunn (ref_39) 2007; 302 Yuan (ref_55) 2018; 9 Blasco (ref_100) 2013; 153 Suetsugu (ref_87) 2018; 99 ref_48 Whittaker (ref_16) 2017; 173 Tomasetti (ref_97) 2019; 116 Dixon (ref_82) 1993; 90 Karagenc (ref_7) 2010; 216 |
References_xml | – volume: 2015 start-page: 568 year: 2015 ident: ref_58 article-title: Terminal deoxynucleotidyl transferase (TdT)-mediated dutp nick-end labeling (TUNEL) for detection of apoptotic cells in Drosophila publication-title: Cold Spring Harb. Protoc. doi: 10.1101/pdb.prot086199 contributor: fullname: Denton – volume: 302 start-page: 536 year: 2007 ident: ref_39 article-title: A spatial and temporal map of FGF/Erk1/2 activity and response repertoires in the early chick embryo publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2006.10.014 contributor: fullname: Lunn – volume: 467 start-page: 474 year: 2010 ident: ref_19 article-title: Checkpoint-dependent inhibition of DNA replication initiation by Sld3 and Dbf4 phosphorylation publication-title: Nature doi: 10.1038/nature09373 contributor: fullname: Zegerman – volume: 116 start-page: 20482 year: 2019 ident: ref_97 article-title: Cell division rates decrease with age, providing a potential explanation for the age-dependent deceleration in cancer incidence publication-title: Proc. Natl. Acad. Sci. USA. doi: 10.1073/pnas.1905722116 contributor: fullname: Tomasetti – ident: ref_26 doi: 10.3390/ijms221910689 – volume: 99 start-page: 1504 year: 2018 ident: ref_87 article-title: Potential role of bird predation in the dispersal of otherwise flightless stick insects publication-title: Ecology doi: 10.1002/ecy.2230 contributor: fullname: Suetsugu – volume: 47 start-page: W199 year: 2019 ident: ref_32 article-title: WebGestalt 2019: Gene set analysis toolkit with revamped UIs and APIs publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkz401 contributor: fullname: Liao – volume: 127 start-page: 215 year: 2018 ident: ref_44 article-title: A guide to classifying mitotic stages and mitotic defects in fixed cells publication-title: Chromosoma doi: 10.1007/s00412-018-0660-2 contributor: fullname: Baudoin – volume: 13 start-page: 144 year: 2004 ident: ref_49 article-title: Quantification of sPLA2-induced early and late apoptosis changes in neuronal cell cultures using combined TUNEL and DAPI staining publication-title: Brain Res. Protoc. doi: 10.1016/j.brainresprot.2004.04.001 contributor: fullname: Daniel – volume: 137 start-page: 3801 year: 2010 ident: ref_64 article-title: Mechanics of head fold formation: Investigating tissue-level forces during early development publication-title: Development doi: 10.1242/dev.054387 contributor: fullname: Varner – volume: 78 start-page: 5060 year: 2018 ident: ref_101 article-title: Replication stress drives constitutive activation of the DNA damage response and radioresistance in glioblastoma stem-like cells publication-title: Cancer Res. doi: 10.1158/0008-5472.CAN-18-0569 contributor: fullname: Carruthers – volume: 14 start-page: 1439 year: 2000 ident: ref_21 article-title: Aberrant cell cycle checkpoint function and early embryonic death in Chk1(−/−) mice publication-title: Genes Dev. doi: 10.1101/gad.14.12.1439 contributor: fullname: Takai – volume: 18 start-page: 1621 year: 1972 ident: ref_93 article-title: Arrest of adult development in debrained pupae of the silkworm, Bombyx mori publication-title: J. Insect Physiol. doi: 10.1016/0022-1910(72)90238-7 contributor: fullname: Ishizaki – volume: 2 start-page: 161 year: 2006 ident: ref_24 article-title: Murine Wee1 plays a critical role in cell cycle regulation and pre-implantation stages of embryonic development publication-title: Int. J. Biol. Sci. doi: 10.7150/ijbs.2.161 contributor: fullname: Tominaga – volume: 34 start-page: 3023 year: 2015 ident: ref_25 article-title: WEE1 murine deficiency induces hyper-activation of APC/C and results in genomic instability and carcinogenesis publication-title: Oncogene doi: 10.1038/onc.2014.239 contributor: fullname: Vassilopoulos – volume: 79 start-page: 7662 year: 2013 ident: ref_73 article-title: DNA double-strand break repair at −15 °C publication-title: Appl. Environ. Microbiol. doi: 10.1128/AEM.02845-13 contributor: fullname: Dieser – volume: 26 start-page: 1225 year: 2020 ident: ref_72 article-title: Cooler temperatures slow the repair of DNA damage in tadpoles exposed to ultraviolet radiation: Implications for amphibian declines at high altitude publication-title: Glob. Chang. Biol. doi: 10.1111/gcb.14837 contributor: fullname: Morison – volume: 132 start-page: jcs226969 year: 2019 ident: ref_103 article-title: An essential role for dNTP homeostasis following CDK-induced replication stress publication-title: J. Cell Sci. doi: 10.1242/jcs.226969 contributor: fullname: Pai – volume: 77 start-page: 1 year: 2002 ident: ref_85 article-title: Avian egg size: Variation within species and inflexibility within individuals publication-title: Biol. Rev. doi: 10.1017/S1464793101005784 contributor: fullname: Christians – volume: 10 start-page: 190299 year: 2020 ident: ref_65 article-title: Molecular anatomy of the pre-primitive-streak chick embryo publication-title: Open Biol. doi: 10.1098/rsob.190299 contributor: fullname: Lee – volume: 97 start-page: 1429 year: 2018 ident: ref_3 article-title: Effects of storage conditions on hatchability, embryonic survival and cytoarchitectural properties in broiler from young and old flocks publication-title: Poult. Sci. doi: 10.3382/ps/pex393 contributor: fullname: Pokhrel – volume: 15 start-page: 550 year: 2014 ident: ref_33 article-title: Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2 publication-title: Genome Biol. doi: 10.1186/s13059-014-0550-8 contributor: fullname: Love – volume: 22 start-page: e2 year: 2020 ident: ref_80 article-title: DNA damage checkpoint kinases in cancer publication-title: Expert Rev. Mol. Med. doi: 10.1017/erm.2020.3 contributor: fullname: Smith – volume: 163 start-page: 103624 year: 2020 ident: ref_60 article-title: Cellular processes driving gastrulation in the avian embryo publication-title: Mech. Dev. doi: 10.1016/j.mod.2020.103624 contributor: fullname: Weijer – volume: 217 start-page: 179 year: 2018 ident: ref_23 article-title: Cyclin B1 is essential for mitosis in mouse embryos, and its nuclear export sets the time for mitosis publication-title: J. Cell Biol. doi: 10.1083/jcb.201612147 contributor: fullname: Strauss – volume: 154 start-page: 36 year: 2011 ident: ref_75 article-title: Oxidative stress, DNA damage and osmolality in the Pacific white shrimp, Litopenaeus vannamei exposed to acute low temperature stress publication-title: Comp. Biochem. Physiol. contributor: fullname: Qiu – volume: 5 start-page: 7825 year: 2015 ident: ref_89 article-title: Extreme convergence in egg-laying strategy across insect orders publication-title: Sci. Rep. doi: 10.1038/srep07825 contributor: fullname: Goldberg – volume: 125 start-page: e56071 year: 2017 ident: ref_52 article-title: High-resolution episcopic microscopy (HREM)—Simple and robust protocols for processing and visualizing organic materials publication-title: J. Vis. Exp. contributor: fullname: Geyer – volume: 8 start-page: 2992 year: 2009 ident: ref_22 article-title: Small-molecule inhibition of Wee1 kinase by MK-1775 selectively sensitizes p53-deficient tumor cells to DNA-damaging agents publication-title: Mol. Cancer Ther. doi: 10.1158/1535-7163.MCT-09-0463 contributor: fullname: Hirai – volume: 11 start-page: 91 year: 2010 ident: ref_43 article-title: Mechanisms of chromosome behaviour during mitosis publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm2832 contributor: fullname: Walczak – ident: ref_45 doi: 10.1371/journal.pone.0039723 – volume: 19 start-page: 1 year: 2017 ident: ref_81 article-title: The control of DNA repair by the cell cycle publication-title: Nat. Cell Biol. doi: 10.1038/ncb3452 contributor: fullname: Hustedt – volume: 211 start-page: 213 year: 2006 ident: ref_51 article-title: High-resolution episcopic microscopy: A rapid technique for high detailed 3D analysis of gene activity in the context of tissue architecture and morphology publication-title: Anat. Embryol. doi: 10.1007/s00429-005-0073-x contributor: fullname: Weninger – volume: 5 start-page: 366 year: 2005 ident: ref_18 article-title: Targeting the cell division cycle in cancer: CDK and cell cycle checkpoint kinase inhibitors publication-title: Curr. Opin. Pharmacol. doi: 10.1016/j.coph.2005.04.009 contributor: fullname: Collins – volume: 49 start-page: 321 year: 1976 ident: ref_5 article-title: From cleavage to primitive streak formation: A complementary normal table and a new look at the first stages of the development of the chick. I. General morphology publication-title: Dev. Biol. doi: 10.1016/0012-1606(76)90178-0 contributor: fullname: Kochav – volume: 5 start-page: a012716 year: 2013 ident: ref_78 article-title: DNA damage sensing by the ATM and ATR kinases publication-title: Cold Spring Harb. Perspect. Biol. doi: 10.1101/cshperspect.a012716 contributor: fullname: Zou – volume: 9 start-page: 6485 year: 2019 ident: ref_92 article-title: Understanding the regulation of overwintering diapause molecular mechanisms in Culex pipiens pallens through comparative proteomics publication-title: Sci. Rep. doi: 10.1038/s41598-019-42961-w contributor: fullname: Zhang – volume: 10 start-page: 29 year: 2019 ident: ref_70 article-title: Cell cycle dynamics during diapause entry and exit in an annual killifish revealed by FUCCI technology publication-title: Evodevo doi: 10.1186/s13227-019-0142-5 contributor: fullname: Dolfi – volume: 12 start-page: 2245 year: 1998 ident: ref_10 article-title: The regulation of E2F by pRB-family proteins publication-title: Genes Dev. doi: 10.1101/gad.12.15.2245 contributor: fullname: Dyson – volume: 114 start-page: 256 year: 2009 ident: ref_90 article-title: Physiological and biochemical investigations on egg stickiness in common carp publication-title: Anim. Reprod. Sci. doi: 10.1016/j.anireprosci.2008.09.005 contributor: fullname: Mansour – volume: 96 start-page: 4399 year: 2017 ident: ref_27 article-title: Cellular and morphological characterization of blastoderms from freshly laid broiler eggs publication-title: Poult. Sci. doi: 10.3382/ps/pex242 contributor: fullname: Pokhrel – volume: 23 start-page: 74 year: 2022 ident: ref_53 article-title: Cell cycle control in cancer publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/s41580-021-00404-3 contributor: fullname: Matthews – volume: 6847 start-page: 684725 year: 2008 ident: ref_63 article-title: Local variations in bone mineral density: A comparison of OCT versus x-ray micro-CT publication-title: Coherence Domain Opt. Methods Opt. Coherence Tomogr. Biomed. XII doi: 10.1117/12.763578 contributor: fullname: Ugryumova – volume: 153 start-page: 1194 year: 2013 ident: ref_100 article-title: The Hallmarks of Aging publication-title: Cell doi: 10.1016/j.cell.2013.05.039 contributor: fullname: Blasco – volume: 43 start-page: W566 year: 2015 ident: ref_37 article-title: ClustVis: A web tool for visualizing clustering of multivariate data using Principal Component Analysis and heatmap publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkv468 contributor: fullname: Metsalu – volume: 9 start-page: 15394 year: 2019 ident: ref_57 article-title: Anti-Tumor Effects of Wee1 Kinase Inhibitor with Radiotherapy in Human Cervical Cancer publication-title: Sci. Rep. doi: 10.1038/s41598-019-51959-3 contributor: fullname: Lee – volume: 9 start-page: 1041 year: 2018 ident: ref_55 article-title: Inhibition of WEE1 Suppresses the Tumor Growth in Laryngeal Squamous Cell Carcinoma publication-title: Front. Pharmacol. doi: 10.3389/fphar.2018.01041 contributor: fullname: Yuan – ident: ref_48 doi: 10.3390/biom11101523 – ident: ref_61 doi: 10.1007/978-94-007-4186-7 – volume: 31 start-page: 3240 year: 2017 ident: ref_9 article-title: Avian blastoderm dormancy arrests cells in G2 and suppresses apoptosis publication-title: FASEB J. doi: 10.1096/fj.201601051RR contributor: fullname: Ko – volume: 129 start-page: 583 year: 2019 ident: ref_28 article-title: A proof of concept study demonstrating that environmental levels of carbamazepine impair early stages of chick embryonic development publication-title: Environ. Int. doi: 10.1016/j.envint.2019.03.064 contributor: fullname: Kohl – volume: 11 start-page: 174 year: 2012 ident: ref_47 article-title: MK1775, A Selective Wee1 Inhibitor, Shows Single-Agent Antitumor Activity Against Sarcoma Cells publication-title: Mol Cancer Ther. doi: 10.1158/1535-7163.MCT-11-0529 contributor: fullname: Kreahling – volume: 56 start-page: 2279 year: 2017 ident: ref_12 article-title: BMP4 enhances hepatocellular carcinoma proliferation by promoting cell cycle progression via ID2/CDKN1B signaling publication-title: Mol. Carcinog. doi: 10.1002/mc.22681 contributor: fullname: Ma – volume: 344 start-page: 881 year: 2010 ident: ref_50 article-title: Analysis of expression and function of FGF-MAPK signaling components in the hindbrain reveals a central role for FGF3 in the regulation of Krox20, mediated by Pea3 publication-title: Dev. Biol. doi: 10.1016/j.ydbio.2010.06.001 contributor: fullname: Weisinger – volume: 2011 start-page: 741213 year: 2011 ident: ref_99 article-title: Superior therapeutic potential of young bone marrow mesenchymal stem cells by direct intramyocardial delivery in aged recipients with acutemyocardial infarction: In Vitro and in Vivo investigation publication-title: J. Tissue Eng. contributor: fullname: Nayan – volume: 116 start-page: 819 year: 1992 ident: ref_66 article-title: The posterior section of the chick’s area pellucida and its involvement in hypoblast and primitive streak formation publication-title: Development doi: 10.1242/dev.116.3.819 contributor: fullname: Debby – volume: 51 start-page: 35 year: 1984 ident: ref_91 article-title: A comparative analysis of the evolution of the egg envelopes and the origin of the yolk publication-title: Bolletino di Zool. doi: 10.1080/11250008409439457 contributor: fullname: Mazzini – volume: 34 start-page: 5240 year: 2020 ident: ref_41 article-title: Conserved role of matrix metalloproteases 2 and 9 in promoting the migration of neural crest cells in avian and mammalian embryos publication-title: FASEB J. doi: 10.1096/fj.201901217RR contributor: fullname: Hanael – volume: 12 start-page: 3348 year: 2013 ident: ref_17 article-title: Wee1 kinase as a target for cancer therapy publication-title: Cell Cycle doi: 10.4161/cc.26062 contributor: fullname: Do – volume: 173 start-page: 279 year: 1996 ident: ref_8 article-title: Skeletal Myogenesis: The Preferred Pathway of Chick Embryo Epiblast Cells in Vitro publication-title: Dev. Biol. doi: 10.1006/dbio.1996.0023 contributor: fullname: Gerhart – ident: ref_62 doi: 10.1371/journal.pone.0126230 – volume: 60 start-page: 313 year: 1991 ident: ref_83 article-title: The Allometry of Egg Size and Number in Insects publication-title: Oikos doi: 10.2307/3545073 contributor: fullname: Berrigan – volume: 343 start-page: 273 year: 1990 ident: ref_6 article-title: Origin of cells giving rise to mesoderm and endoderm in chick embryo publication-title: Nature doi: 10.1038/343273a0 contributor: fullname: Stern – volume: 81 start-page: 806 year: 2012 ident: ref_84 article-title: Spatial variation in egg size and egg number reflects trade-offs and bet-hedging in a freshwater fish publication-title: J. Anim. Ecol. doi: 10.1111/j.1365-2656.2012.01961.x contributor: fullname: Morrongiello – volume: 5 start-page: 4487 year: 2014 ident: ref_59 article-title: Receptor-interacting protein 140 attenuates endoplasmic reticulum stress in neurons and protects against cell death publication-title: Nat. Commun. doi: 10.1038/ncomms5487 contributor: fullname: Feng – volume: 16 start-page: 2570 year: 1996 ident: ref_11 article-title: Id2 specifically alters regulation of the cell cycle by tumor suppressor proteins publication-title: Mol. Cell. Biol. doi: 10.1128/MCB.16.6.2570 contributor: fullname: Lasorella – volume: 90 start-page: 457 year: 1993 ident: ref_82 article-title: Egg and cluster size in lady bird beetles (Coleoptera: Coccinellidae): The direct and indirect effects of aphid abundance publication-title: Eur. J. Entomol. contributor: fullname: Dixon – volume: 99 start-page: 1047 year: 2019 ident: ref_96 article-title: Cellular senescence: Aging, cancer, and injury publication-title: Physiol. Rev. doi: 10.1152/physrev.00020.2018 contributor: fullname: Calcinotto – volume: 9 start-page: 6111 year: 2019 ident: ref_88 article-title: Extending r/K selection with a maternal risk-management model that classifies animal species into divergent natural selection categories publication-title: Sci. Rep. doi: 10.1038/s41598-019-42562-7 contributor: fullname: Cassill – volume: 74 start-page: 463 year: 1993 ident: ref_104 article-title: Human wee1 maintains mitotic timing by protecting the nucleus from cytoplasmically activated cdc2 kinase publication-title: Cell doi: 10.1016/0092-8674(93)80048-J contributor: fullname: Heald – volume: 8 start-page: 30 year: 2013 ident: ref_15 article-title: The kinetics of G2 and M transitions regulated by B cyclins publication-title: PLoS ONE contributor: fullname: Huang – volume: 100 start-page: 101227 year: 2021 ident: ref_4 article-title: The chick blastoderm during diapause, a landmark for optimization of preincubation storage conditions publication-title: Poult. Sci. doi: 10.1016/j.psj.2021.101227 contributor: fullname: Pokhrel – volume: 59 start-page: 1317 year: 2002 ident: ref_14 article-title: Cyclin A in cell cycle control and cancer publication-title: Cell. Mol. Life Sci. doi: 10.1007/s00018-002-8510-y contributor: fullname: Yam – ident: ref_30 doi: 10.1186/s12859-017-1934-z – volume: 131 start-page: 571 year: 2004 ident: ref_71 article-title: Morphogenesis during Xenopus gastrulation requires Wee1-mediated inhibition of cell proliferation publication-title: Development doi: 10.1242/dev.00971 contributor: fullname: Murakami – volume: 8 start-page: 13920 year: 2018 ident: ref_40 article-title: Neural stem cells deriving from chick embryonic hindbrain recapitulate hindbrain development in culture publication-title: Sci. Rep. doi: 10.1038/s41598-018-32203-w contributor: fullname: Peretz – volume: 10 start-page: 9930 year: 2020 ident: ref_56 article-title: Antitumor effect of a WEE1 inhibitor and potentiation of olaparib sensitivity by DNA damage response modulation in triple-negative breast cancer publication-title: Sci. Rep. doi: 10.1038/s41598-020-66018-5 contributor: fullname: Ha – volume: 64 start-page: 137 year: 2017 ident: ref_74 article-title: Immune and physiological responses of pufferfish (Takifugu obscurus) under cold stress publication-title: Fish Shellfish Immunol. doi: 10.1016/j.fsi.2017.03.003 contributor: fullname: Cheng – volume: 23 start-page: 1289 year: 2007 ident: ref_38 article-title: Enhancements and modifications of primer design program Primer3 publication-title: Bioinformatics doi: 10.1093/bioinformatics/btm091 contributor: fullname: Koressaar – volume: 14 start-page: 518 year: 2013 ident: ref_13 article-title: Control of cell cycle transcription during G1 and S phases publication-title: Nat. Rev. Mol. Cell Biol. doi: 10.1038/nrm3629 contributor: fullname: Bertoli – volume: 19 start-page: 3316 year: 1999 ident: ref_35 article-title: Comprehensive gene and pathway analysis of cervical cancer progression publication-title: Oncol. Lett. contributor: fullname: Yi – volume: 20 start-page: 127 year: 2011 ident: ref_98 article-title: Effects of long-term culture on human embryonic stem cell aging publication-title: Stem Cells Dev. doi: 10.1089/scd.2009.0475 contributor: fullname: Xie – volume: 117 start-page: 25590 year: 2020 ident: ref_105 article-title: Birds advancing lay dates with warming springs face greater risk of chick mortality publication-title: Proc. Natl. Acad. Sci. USA doi: 10.1073/pnas.2009864117 contributor: fullname: Shipley – volume: 10 start-page: 161 year: 2012 ident: ref_42 article-title: A framework for image-based classification of mitotic cells in asynchronous populations publication-title: Assay Drug Dev. Technol. doi: 10.1089/adt.2011.0397 contributor: fullname: Slattery – volume: 37 start-page: 872 year: 2016 ident: ref_68 article-title: Targeting WEE1 Kinase in Cancer publication-title: Trends Pharmacol. Sci. doi: 10.1016/j.tips.2016.06.006 contributor: fullname: Matheson – ident: ref_95 doi: 10.1371/journal.pgen.1005787 – volume: 14 start-page: 3580 year: 2017 ident: ref_54 article-title: WEE1 inhibition by MK1775 as a single-agent therapy inhibits ovarian cancer viability publication-title: Oncol. Lett. doi: 10.3892/ol.2017.6584 contributor: fullname: Zhang – volume: 30 start-page: 1224 year: 2020 ident: ref_102 article-title: Exploiting replicative stress in gynecological cancers as a therapeutic strategy publication-title: Int. J. Gynecol. Cancer doi: 10.1136/ijgc-2020-001277 contributor: fullname: Ngoi – volume: 819 start-page: 111694 year: 2020 ident: ref_20 article-title: WEE1 kinase limits CDK activities to safeguard DNA replication and mitotic entry publication-title: Mutat. Res. Fundam. Mol. Mech. Mutagen. contributor: fullname: Petrosius – volume: 279 start-page: 2299 year: 2012 ident: ref_94 article-title: Arrested embryonic development: A review of strategies to delay hatching in egg-laying reptiles publication-title: Proc. R. Soc. B Biol. Sci. doi: 10.1098/rspb.2012.0100 contributor: fullname: Rafferty – volume: 173 start-page: 83 year: 2017 ident: ref_16 article-title: Inhibitors of cyclin-dependent kinases as cancer therapeutics publication-title: Pharmacol. Ther. doi: 10.1016/j.pharmthera.2017.02.008 contributor: fullname: Whittaker – volume: 10 start-page: 155 year: 2004 ident: ref_76 article-title: ATM and ATR: Sensing DNA damage publication-title: World J. Gastroenterol. doi: 10.3748/wjg.v10.i2.155 contributor: fullname: Yang – ident: ref_29 – volume: 100 start-page: 1204 year: 2019 ident: ref_69 article-title: Distinct dormancy progression depending on embryonic regions during mouse embryonic diapause publication-title: Biol. Reprod. doi: 10.1093/biolre/ioz017 contributor: fullname: Kamemizu – volume: 197 start-page: 3 year: 2015 ident: ref_67 article-title: High-resolution episcopic microscopy (HREM): A useful technique for research in wound care publication-title: Ann. Anat. doi: 10.1016/j.aanat.2014.10.012 contributor: fullname: Geyer – volume: 139 start-page: 1059 year: 2012 ident: ref_1 article-title: The hypoblast (visceral endoderm): An evo-devo perspective publication-title: Development doi: 10.1242/dev.070730 contributor: fullname: Stern – volume: 7 start-page: 18083 year: 2017 ident: ref_34 article-title: RNA-Seq reveals seven promising candidate genes affecting the proportion of thick egg albumen in layer-type chickens publication-title: Sci. Rep. doi: 10.1038/s41598-017-18389-5 contributor: fullname: Wan – volume: 28 start-page: 1947 year: 2019 ident: ref_36 article-title: Toward understanding the origin and evolution of cellular organisms publication-title: Protein Sci. doi: 10.1002/pro.3715 contributor: fullname: Kanehisa – volume: 9 start-page: 671 year: 2012 ident: ref_31 article-title: NIH Image to ImageJ: 25 years of image analysis publication-title: Nat. Methods doi: 10.1038/nmeth.2089 contributor: fullname: Schneider – volume: 86 start-page: 1020 year: 2007 ident: ref_2 article-title: Egg storage and the embryo publication-title: Poult. Sci. doi: 10.1093/ps/86.5.1020 contributor: fullname: Fasenko – volume: 9 start-page: 514 year: 2010 ident: ref_46 article-title: MK-1775, a small molecule Wee1 inhibitor, enhances antitumor efficacy of various DNA-damaging agents, including 5-fluorouracil publication-title: Cancer Biol. Ther. doi: 10.4161/cbt.9.7.11115 contributor: fullname: Hirai – volume: 216 start-page: 16 year: 2010 ident: ref_7 article-title: Tissue distribution of cells derived from the area opaca in heterospecific quail-chick blastodermal chimeras publication-title: J. Anat. doi: 10.1111/j.1469-7580.2009.01168.x contributor: fullname: Karagenc – ident: ref_77 doi: 10.1016/B978-0-12-380888-2.00003-0 – volume: 18 start-page: 652 year: 2007 ident: ref_86 article-title: Mothers adjust egg size to helper number in a cooperatively breeding cichlid publication-title: Behav. Ecol. doi: 10.1093/beheco/arm026 contributor: fullname: Taborsky – ident: ref_79 doi: 10.3390/cancers13040795 |
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Snippet | Avian blastoderm can enter into diapause when kept at low temperatures and successfully resume development (SRD) when re-incubated in body temperature. These... |
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SubjectTerms | Blastoderm Body temperature Bromodeoxyuridine Cell cycle Cell division Cell number chicken embryonic blastoderm chicken embryonic diapause Cyclin-dependent kinases Diapause Eggs Embryos G2/M transition Genomes high-resolution episcopic microscopy (HREM) Histone H3 Histones Kinases Low temperature Microscopy Morphology Phenotypes WEE1 |
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Title | HREM, RNAseq and Cell Cycle Analyses Reveal the Role of the G2/M-Regulatory Protein, WEE1, on the Survivability of Chicken Embryos during Diapause |
URI | https://www.ncbi.nlm.nih.gov/pubmed/35453529 https://www.proquest.com/docview/2652955434 https://www.proquest.com/docview/2654291840/abstract/ https://pubmed.ncbi.nlm.nih.gov/PMC9033001 https://doaj.org/article/48864f62546241128225bd2072b0180d |
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