Microenvironmental modulation in tandem with human stem cell transplantation enhances functional recovery after chronic complete spinal cord injury

• Published in: Biomaterials Vol. 295; p. 122002
• Main Authors: Hashimoto, Shogo, Nagoshi, Narihito, Shinozaki, Munehisa, Nakanishi, Katsuyuki, Suematsu, Yu, Shibata, Takahiro, Kawai, Momotaro, Kitagawa, Takahiro, Ago, Kentaro, Kamata, Yasuhiro, Yasutake, Kaori, Koya, Ikuko, Ando, Yoshinari, Minoda, Aki, Shindo, Tomoko, Shibata, Shinsuke, Matsumoto, Morio, Nakamura, Masaya, Okano, Hideyuki
• Format: Journal Article
• Language: English
• Published: Netherlands Elsevier Ltd 01.04.2023
• Subjects: Axons - pathology; Cell transplantation therapy; Chronic phase; Hepatocyte growth factor; Humans; iPS cell; Nerve Regeneration; Neurons - metabolism; Recovery of Function; Scaffold; Spinal Cord - pathology; Spinal Cord Injuries - pathology; Spinal cord transection injury; Stem Cell Transplantation - methods; spinal cord injury; human iPS cell-derived neural stem/progenitor cells; Hepatocyte growth factor; Chronic phase; pelnac G plus; Spinal cord transection injury; iPS cell; adeno-associated virus; Scaffold; wheat germ agglutinin; Cell transplantation therapy

While rapid advancements in regenerative medicine strategies for spinal cord injury (SCI) have been made, most research in this field has focused on the early stages of incomplete injury. However, the majority of patients experience chronic severe injury; therefore, treatments for these situations a...