Non-cytochrome P450-mediated bioactivation and its toxicological relevance

• Published in: Drug metabolism reviews Vol. 48; no. 4; pp. 473 - 501
• Main Authors: Gan, Jinping, Ma, Shuguang, Zhang, Donglu
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.11.2016
• Subjects: Animals; Biotransformation; conjugation reactions; Cytochrome P-450 Enzyme System - metabolism; Drug bioactivation; Drug-Related Side Effects and Adverse Reactions; Humans; Hydrolysis; hydrolytic reactions; Metabolic Detoxication, Phase II; non-CYP enzymes; Oxidation-Reduction; Pharmaceutical Preparations - metabolism; reductive reactions; conjugation reactions; reductive reactions; hydrolytic reactions; non-CYP enzymes; Drug bioactivation

The bioactivation of drugs is often associated with toxicological outcomes; however, for most cases, the causal relationship between bioactivation and toxicity is not well established despite extensive research that attempts to elucidate the mechanisms leading to the formation of chemically reactive...