GMI, an immunomodulatory protein from Ganoderma microsporum, induces autophagy in non-small cell lung cancer cells

• Published in: Autophagy Vol. 7; no. 8; pp. 873 - 882
• Main Authors: Hsin, I-Lun, Ou, Chu-Chyn, Wu, Tzu-Chin, Jan, Ming-Shiou, Wu, Ming-Fang, Chiu, Ling-Yen, Lue, Ko-Huang, Ko, Jiunn-Liang
• Format: Journal Article
• Language: English
• Published: United States Taylor & Francis 01.08.2011
• Subjects: Adenine - analogs & derivatives; Adenine - pharmacology; Animals; Apoptosis - drug effects; Autophagy - drug effects; Binding; Biology; Bioscience; Calcium; Calcium - metabolism; Cancer; Carcinoma, Non-Small-Cell Lung - pathology; Cell; Cell Proliferation - drug effects; Cell Survival - drug effects; Cycle; Fungal Proteins - pharmacology; Ganoderma - chemistry; Gene Silencing - drug effects; Immunologic Factors - pharmacology; Landes; Lung Neoplasms - pathology; Mice; Microtubule-Associated Proteins - metabolism; Organogenesis; Proteins; Signal Transduction - drug effects; Tumor Stem Cell Assay; Tumor Suppressor Protein p53 - metabolism; Xenograft Model Antitumor Assays

Autophagy is a self-digestive process that degrades the cytoplasmic constituents. Immunomodulatory protein, one major bioactive component of Ganoderma, has antitumor activity. In this study, recombinant fungal immunomodulatory protein, GMI, was cloned from Ganoderma microsporum and purified. We demo...