High-throughput analysis of immunoglobulin G glycosylation

• Published in: Expert review of proteomics Vol. 13; no. 5; p. 523
• Main Authors: Trbojević-Akmačić, Irena, Vilaj, Marija, Lauc, Gordan
• Format: Journal Article
• Language: English
• Published: England 03.05.2016
• Subjects: Chromatography, High Pressure Liquid - methods; Electrophoresis, Capillary - methods; Glycomics - methods; Glycosylation; High-Throughput Screening Assays - methods; Humans; Immunoglobulin G - analysis; Immunoglobulin G - chemistry; Immunoglobulin G - isolation & purification; Immunoglobulin G - metabolism; Mass Spectrometry - methods; Proteomics - methods; Capillary electrophoresis; high-throughput; ultra-performance liquid chromatography; IgG; mass spectrometry; N-glycosylation; glycan biomarker

Glycosylation of immunoglobulin G (IgG) is important for its effector functions and was shown to be related to age, sex and disease status of an individual. Adding glycomic information to genome-wide association studies (GWAS) and large clinical trials is enabling insight into the functional relevan...