The standard international prognostic index for predicting the risk of CNS involvement in DLBCL without specific prophylaxis
Central nervous system (CNS) involvement is a serious complication in patients with diffuse large B-cell lymphoma (DLBCL) and evaluating CNS risk is an important issue. Using the standard international prognostic index (IPI) and CNS-IPI, a recently proposed model including IPI risk factors and adren...
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Published in | Leukemia & lymphoma Vol. 59; no. 1; pp. 97 - 104 |
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Main Authors | , , , , , , , , , , , , , , , , , , , , , , , , , |
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Language | English |
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Taylor & Francis
02.01.2018
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Abstract | Central nervous system (CNS) involvement is a serious complication in patients with diffuse large B-cell lymphoma (DLBCL) and evaluating CNS risk is an important issue. Using the standard international prognostic index (IPI) and CNS-IPI, a recently proposed model including IPI risk factors and adrenal/kidney involvement, we assessed CNS risk in 1220 untreated DLBCL patients who received R-CHOP without prophylaxis. According to the standard IPI, the cumulative incidences of CNS involvement at 2 years were 1.3, 4.6, 8.8, and 12.7% in the low-, low-intermediate-, high-intermediate-, and high-risk groups, respectively (p <.001). This result is comparable with that of the CNS-IPI. Patients with breast involvement tended to have lower risk according to the standard IPI but showed frequent CNS involvement, similar to patients with testis involvement. The standard IPI is also a useful predictor of CNS involvement. Patients with breast/testis involvement would be candidates for prophylaxis regardless of the standard IPI risk. |
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AbstractList | Central nervous system (CNS) involvement is a serious complication in patients with diffuse large B-cell lymphoma (DLBCL) and evaluating CNS risk is an important issue. Using the standard international prognostic index (IPI) and CNS-IPI, a recently proposed model including IPI risk factors and adrenal/kidney involvement, we assessed CNS risk in 1220 untreated DLBCL patients who received R-CHOP without prophylaxis. According to the standard IPI, the cumulative incidences of CNS involvement at 2 years were 1.3, 4.6, 8.8, and 12.7% in the low-, low-intermediate-, high-intermediate-, and high-risk groups, respectively (p <.001). This result is comparable with that of the CNS-IPI. Patients with breast involvement tended to have lower risk according to the standard IPI but showed frequent CNS involvement, similar to patients with testis involvement. The standard IPI is also a useful predictor of CNS involvement. Patients with breast/testis involvement would be candidates for prophylaxis regardless of the standard IPI risk. Central nervous system (CNS) involvement is a serious complication in patients with diffuse large B-cell lymphoma (DLBCL) and evaluating CNS risk is an important issue. Using the standard international prognostic index (IPI) and CNS-IPI, a recently proposed model including IPI risk factors and adrenal/kidney involvement, we assessed CNS risk in 1220 untreated DLBCL patients who received R-CHOP without prophylaxis. According to the standard IPI, the cumulative incidences of CNS involvement at 2 years were 1.3, 4.6, 8.8, and 12.7% in the low-, low-intermediate-, high-intermediate-, and high-risk groups, respectively (p <.001). This result is comparable with that of the CNS-IPI. Patients with breast involvement tended to have lower risk according to the standard IPI but showed frequent CNS involvement, similar to patients with testis involvement. The standard IPI is also a useful predictor of CNS involvement. Patients with breast/testis involvement would be candidates for prophylaxis regardless of the standard IPI risk. |
Author | Tamura, Kazuo Okamoto, Rumiko Watanabe, Reina Numata, Ayumi Takeuchi, Kengo Ohshima, Rika Takahashi, Hiromichi Yamamoto, Wataru Yokoyama, Masahiro Kinoshita, Tomohiro Sunami, Kazutaka Shibayama, Hirohiko Miura, Ikuo Yano, Takahiro Shimazu, Yutaka Moriuchi, Yukiyoshi Murayama, Kayoko Tomita, Naoto Masaki, Yasufumi Kikuchi, Ako Hashimoto, Chizuko Tsunoda, Saburo Takimoto, Rishu Sato, Kazuya Nakajima, Hideaki Yamamoto, Masahide |
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SubjectTerms | Adolescent Adult Aged Aged, 80 and over Antibodies, Monoclonal, Murine-Derived Antineoplastic Combined Chemotherapy Protocols central nervous system Central Nervous System Neoplasms - epidemiology Central Nervous System Neoplasms - mortality Central Nervous System Neoplasms - prevention & control Central Nervous System Neoplasms - secondary Cyclophosphamide diffuse large B-cell lymphoma Doxorubicin Female Humans Incidence International prognostic index Lymphoma, Large B-Cell, Diffuse - drug therapy Lymphoma, Large B-Cell, Diffuse - epidemiology Lymphoma, Large B-Cell, Diffuse - mortality Lymphoma, Large B-Cell, Diffuse - pathology Male Middle Aged Prednisone Prognosis prophylaxis R-CHOP Risk Vincristine Young Adult |
Title | The standard international prognostic index for predicting the risk of CNS involvement in DLBCL without specific prophylaxis |
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