Genetic Variants in ICAM1, PPARGC1A and MTHFR Are Potentially Associated with Different Phenotypes of Diabetic Retinopathy

• Published in: Ophthalmologica (Basel) Vol. 232; no. 3; pp. 156 - 162
• Main Authors: Simões, Maria José, Lobo, Conceição, Egas, Conceição, Nunes, Sandrina, Carmona, Susana, Costa, Miguel Ângelo, Duarte, Tânia, Ribeiro, Luísa, Faro, Carlos, Cunha-Vaz, José G.
• Format: Journal Article
• Language: English
• Published: Basel, Switzerland S. Karger AG 01.01.2014
• Subjects: Adult; Aged; Diabetes Mellitus, Type 2 - genetics; Diabetic Retinopathy - genetics; Female; Genetic Association Studies; Genotyping Techniques; Humans; Intercellular Adhesion Molecule-1 - genetics; Male; Methylenetetrahydrofolate Reductase (NADPH2) - genetics; Middle Aged; Original Paper; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-alpha; Phenotype; Polymorphism, Single Nucleotide; Transcription Factors - genetics; Diabetic retinopathy; Genetics; Diabetes

Purpose: To explore phenotype-genotype correlations that may contribute to a better understanding of diabetic retinopathy (DR). Procedures: An exploratory association study was performed to identify genetic variants associated with non-proliferative DR (NPDR) in 307 type 2 diabetic patients who were...