Mucosubstances in classification of serous and mucinous ovarian tumors: A morphometrical study
108 serous and 106 mucinous ovarian cystadenomas of varying malignancy were studied with the saliva-periodic acid-Schiff (SPAS) reaction and with the Alcian blue (AB) pH 2.7 method, which stain neutral and acid mucosubstances, respectively. Positively stained mucin was quantitated morphometrically a...
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Published in | European journal of obstetrics & gynecology and reproductive biology Vol. 22; no. 3; pp. 139 - 144 |
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Main Author | |
Format | Journal Article |
Language | English |
Published |
Shannon
Elsevier Ireland Ltd
01.07.1986
Elsevier |
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Abstract | 108 serous and 106 mucinous ovarian cystadenomas of varying malignancy were studied with the saliva-periodic acid-Schiff (SPAS) reaction and with the Alcian blue (AB) pH 2.7 method, which stain neutral and acid mucosubstances, respectively. Positively stained mucin was quantitated morphometrically and the measured parameters were tested by discriminant analysis. As expected, the mucinous tumors were more positive for mucin than the serous ones. Also the borderline tumors contained more mucin than their benign or malignant counterparts. The best discriminating capacity for mucin was obtained in serous tumors with the AB stain and in mucinous tumors with the SPAS reaction. The ratio of neutral to acid mucosubstances decreased in mucinous cystadenomas with increasing malignancy. |
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AbstractList | 108 serous and 106 mucinous ovarian cystadenomas of varying malignancy were studied with the saliva-periodic acid-Schiff (SPAS) reaction and with the Alcian blue (AB) pH 2.7 method, which stain neutral and acid mucosubstances, respectively. Positively stained mucin was quantitated morphometrically and the measured parameters were tested by discriminant analysis. As expected, the mucinous tumors were more positive for mucin than the serous ones. Also the borderline tumors contained more mucin than their benign or malignant counterparts. The best discriminating capacity for mucin was obtained in serous tumors with the AB stain and in mucinous tumors with the SPAS reaction. The ratio of neutral to acid mucosubstances decreased in mucinous cystadenomas with increasing malignancy. |
Author | Aalto, Marja-Leena |
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Keywords | saliva-periodic acid-Schiff (SPAS) stain tumor classification Alcian blue (AB) stain Human Pathology Ovary Serous cystadenoma Classification Tumor Morphometry Mucinous cystadenoma Female genital diseases |
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References | Baak, Fox, Langley, Buckley (BIB5) 1985; 4 Humason (BIB8) 1979 Serov, Scully, Sobin (BIB12) 1973 Zugibe (BIB11) 1970 Aure, Høeg, Kolstad (BIB1) 1971; 37 Baak, van der Ley (BIB4) 1984; 37 Garcia-Bunuel, Monis (BIB7) 1964; 17 Baak, Blanco, Kurver, Langley, Boon, Lindeman, Overdiep, Nieuwlaat, Brekelmans (BIB2) 1981; 5 Klemi, Nevalainen (BIB9) 1978; 86 Long, Sommers (BIB14) 1969; 12 Baak, Lindeman, Overdiep, Langley (BIB3) 1982; 13 Aalto, Collan (BIB6) 1983; 2 Klemi (BIB10) 1978; 86 Morrison (BIB13) 1982 Long (10.1016/0028-2243(86)90058-4_BIB14) 1969; 12 Serov (10.1016/0028-2243(86)90058-4_BIB12) 1973 Aure (10.1016/0028-2243(86)90058-4_BIB1) 1971; 37 Baak (10.1016/0028-2243(86)90058-4_BIB5) 1985; 4 Klemi (10.1016/0028-2243(86)90058-4_BIB10) 1978; 86 Humason (10.1016/0028-2243(86)90058-4_BIB8) 1979 Baak (10.1016/0028-2243(86)90058-4_BIB2) 1981; 5 Zugibe (10.1016/0028-2243(86)90058-4_BIB11) 1970 Morrison (10.1016/0028-2243(86)90058-4_BIB13) 1982 Baak (10.1016/0028-2243(86)90058-4_BIB4) 1984; 37 Garcia-Bunuel (10.1016/0028-2243(86)90058-4_BIB7) 1964; 17 Baak (10.1016/0028-2243(86)90058-4_BIB3) 1982; 13 Aalto (10.1016/0028-2243(86)90058-4_BIB6) 1983; 2 Klemi (10.1016/0028-2243(86)90058-4_BIB9) 1978; 86 |
References_xml | – volume: 12 start-page: 937 year: 1969 end-page: 954 ident: BIB14 article-title: Staging, grading and histochemistry of ovarian epithelial tumors publication-title: Clin Obstet Gynecol contributor: fullname: Sommers – volume: 13 start-page: 51 year: 1982 end-page: 55 ident: BIB3 article-title: Disagreement of histopathological diagnoses of different pathologists in ovarian tumors — with some theoretical considerations publication-title: Eur J Obstet Gynecol Reprod Biol contributor: fullname: Langley – year: 1973 ident: BIB12 article-title: Histological typing of the ovarian tumours contributor: fullname: Sobin – volume: 37 start-page: 1 year: 1971 end-page: 9 ident: BIB1 article-title: Clinical and histologic studies of ovarian carcinoma. Long-term follow-up of 990 cases publication-title: Obstet Gynecol contributor: fullname: Kolstad – volume: 4 start-page: 186 year: 1985 end-page: 191 ident: BIB5 article-title: The prognostic value of morphometry in ovarian epithelial tumors of borderline malignancy publication-title: Int J Gynecol Pathol contributor: fullname: Buckley – volume: 37 start-page: 1110 year: 1984 end-page: 1113 ident: BIB4 article-title: Borderline or malignant ovarian tumour? A case report of decision making with morphometry publication-title: J Clin Pathol contributor: fullname: van der Ley – start-page: 61 year: 1970 end-page: 92 ident: BIB11 article-title: The carbohydrates publication-title: Diagnostic histochemistry contributor: fullname: Zugibe – volume: 5 start-page: 353 year: 1981 end-page: 360 ident: BIB2 article-title: Quantitation of borderline and malignant mucinous ovarian tumours publication-title: Histopathology contributor: fullname: Brekelmans – year: 1982 ident: BIB13 article-title: SPSS-11. The SPSS Batch System for the DEC PDP-11 contributor: fullname: Morrison – volume: 2 start-page: 395 year: 1983 end-page: 399 ident: BIB6 article-title: Periodic acid-Schiff (PAS) stain in serous tumours and clear cell carcinomas of the ovary. A morphometric study publication-title: Acta Stereol contributor: fullname: Collan – start-page: 208 year: 1979 end-page: 213 ident: BIB8 article-title: PAS and Feulgen techniques, and related reactions publication-title: Animal tissue techniques contributor: fullname: Humason – volume: 86 start-page: 465 year: 1978 end-page: 470 ident: BIB10 article-title: Pathology of mucinous ovarian cystadenomas. 1. Argyrophil and argentaffin cells and epithelial mucosubstances publication-title: Acta Pathol Microbiol Scand [A] contributor: fullname: Klemi – volume: 86 start-page: 303 year: 1978 end-page: 312 ident: BIB9 article-title: Ultrastructural and histochemical observations on serous ovarian cystadenomas publication-title: Acta Pathol Microbiol Scand [A] contributor: fullname: Nevalainen – volume: 17 start-page: 1108 year: 1964 end-page: 1118 ident: BIB7 article-title: Histochemical observations on mucins in human ovarian neoplasms publication-title: Cancer contributor: fullname: Monis – year: 1973 ident: 10.1016/0028-2243(86)90058-4_BIB12 contributor: fullname: Serov – volume: 37 start-page: 1110 year: 1984 ident: 10.1016/0028-2243(86)90058-4_BIB4 article-title: Borderline or malignant ovarian tumour? A case report of decision making with morphometry publication-title: J Clin Pathol doi: 10.1136/jcp.37.10.1110 contributor: fullname: Baak – volume: 5 start-page: 353 year: 1981 ident: 10.1016/0028-2243(86)90058-4_BIB2 article-title: Quantitation of borderline and malignant mucinous ovarian tumours publication-title: Histopathology doi: 10.1111/j.1365-2559.1981.tb01797.x contributor: fullname: Baak – volume: 2 start-page: 395 year: 1983 ident: 10.1016/0028-2243(86)90058-4_BIB6 article-title: Periodic acid-Schiff (PAS) stain in serous tumours and clear cell carcinomas of the ovary. A morphometric study publication-title: Acta Stereol contributor: fullname: Aalto – volume: 37 start-page: 1 year: 1971 ident: 10.1016/0028-2243(86)90058-4_BIB1 article-title: Clinical and histologic studies of ovarian carcinoma. Long-term follow-up of 990 cases publication-title: Obstet Gynecol contributor: fullname: Aure – volume: 12 start-page: 937 year: 1969 ident: 10.1016/0028-2243(86)90058-4_BIB14 article-title: Staging, grading and histochemistry of ovarian epithelial tumors publication-title: Clin Obstet Gynecol doi: 10.1097/00003081-196912040-00007 contributor: fullname: Long – volume: 17 start-page: 1108 year: 1964 ident: 10.1016/0028-2243(86)90058-4_BIB7 article-title: Histochemical observations on mucins in human ovarian neoplasms publication-title: Cancer doi: 10.1002/1097-0142(196409)17:9<1108::AID-CNCR2820170903>3.0.CO;2-8 contributor: fullname: Garcia-Bunuel – volume: 13 start-page: 51 year: 1982 ident: 10.1016/0028-2243(86)90058-4_BIB3 article-title: Disagreement of histopathological diagnoses of different pathologists in ovarian tumors — with some theoretical considerations publication-title: Eur J Obstet Gynecol Reprod Biol doi: 10.1016/0028-2243(82)90037-5 contributor: fullname: Baak – start-page: 208 year: 1979 ident: 10.1016/0028-2243(86)90058-4_BIB8 article-title: PAS and Feulgen techniques, and related reactions contributor: fullname: Humason – year: 1982 ident: 10.1016/0028-2243(86)90058-4_BIB13 contributor: fullname: Morrison – volume: 86 start-page: 303 year: 1978 ident: 10.1016/0028-2243(86)90058-4_BIB9 article-title: Ultrastructural and histochemical observations on serous ovarian cystadenomas publication-title: Acta Pathol Microbiol Scand [A] contributor: fullname: Klemi – start-page: 61 year: 1970 ident: 10.1016/0028-2243(86)90058-4_BIB11 article-title: The carbohydrates contributor: fullname: Zugibe – volume: 4 start-page: 186 year: 1985 ident: 10.1016/0028-2243(86)90058-4_BIB5 article-title: The prognostic value of morphometry in ovarian epithelial tumors of borderline malignancy publication-title: Int J Gynecol Pathol doi: 10.1097/00004347-198509000-00003 contributor: fullname: Baak – volume: 86 start-page: 465 year: 1978 ident: 10.1016/0028-2243(86)90058-4_BIB10 article-title: Pathology of mucinous ovarian cystadenomas. 1. Argyrophil and argentaffin cells and epithelial mucosubstances publication-title: Acta Pathol Microbiol Scand [A] contributor: fullname: Klemi |
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SubjectTerms | Alcian Blue Alcian blue (AB) stain Biological and medical sciences Cystadenoma - classification Cystadenoma - pathology Female Female genital diseases Gynecology. Andrology. Obstetrics Humans Medical sciences Mucins - analysis Orosomucoid - analysis Ovarian Neoplasms - classification Ovarian Neoplasms - pathology Periodic Acid-Schiff Reaction - methods saliva-periodic acid-Schiff (SPAS) stain tumor classification Tumors |
Title | Mucosubstances in classification of serous and mucinous ovarian tumors: A morphometrical study |
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