Correlations between Hypothalamus-Pituitary-Adrenal Axis Parameters Depend on Age and Learning Capacity

• Published in: Endocrinology (Philadelphia) Vol. 146; no. 3; pp. 1372 - 1381
• Main Authors: Meijer, O. C, Topic, B, Steenbergen, P. J, Jocham, G, Huston, J. P, Oitzl, M. S
• Format: Journal Article
• Language: English
• Published: Bethesda, MD Endocrine Society 01.03.2005
• Subjects: Adrenal Glands - physiology; Aging; Animals; Arginine Vasopressin - metabolism; Biological and medical sciences; Corticosterone - metabolism; Fundamental and applied biological sciences. Psychology; Glucocorticoids - metabolism; Hippocampus - metabolism; Hypothalamus - metabolism; Hypothalamus - physiology; In Situ Hybridization; Learning; Male; Maze Learning; Pituitary Gland - physiology; Pituitary-Adrenal System; Plasmids - metabolism; Rats; Rats, Wistar; Receptors, Glucocorticoid - metabolism; Receptors, Mineralocorticoid - metabolism; RNA, Messenger - metabolism; Time Factors; Vertebrates: endocrinology; Correlation; Endocrine gland; Central nervous system; Pituitary gland; Hypothalamus; Age; Encephalon

Glucocorticoid hormones are released after activation of the hypothalamus-pituitary-adrenal (HPA) axis and in the brain can modulate synaptic plasticity and memory formation. Clear individual differences in spatial learning and memory in the water maze allowed classification of groups of young (3 mo...