The emerging roles of B cells as partners and targets in periodontitis

• Published in: Autoimmunity (Chur, Switzerland) Vol. 50; no. 1; pp. 61 - 70
• Main Author: Zouali, Moncef
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 01.02.2017; Taylor & Francis Group
• Subjects: Animals; Antigens - immunology; Autoantibodies - immunology; Autoimmunity; B-Lymphocytes - immunology; B-Lymphocytes - metabolism; B-Lymphocytes - pathology; BAFF; Bone Resorption - immunology; Bone Resorption - metabolism; Chronic Disease; Cytokines - metabolism; Humans; Immunity; Lymphocyte Activation - immunology; Lymphocyte Count; osteoclast; Osteoclasts - metabolism; Periodontal Diseases - etiology; Periodontal Diseases - metabolism; Periodontal Diseases - pathology; Periodontitis - etiology; Periodontitis - metabolism; Periodontitis - pathology; plasma cell; Plasma Cells - immunology; Plasma Cells - metabolism; RANK Ligand - metabolism; RANKL; Rheumatoid arthritis; Signal Transduction; BAFF; RANKL; autoimmunity; osteoclast; plasma cell; Rheumatoid arthritis

Initial studies of periodontal disease suggested that T cell-mediated immunity against oral Gram-negative microorganisms is a key player in the pathogenesis of this inflammatory disease. Recent investigations, however, revealed that B cells are also engaged. Given their chief role in innate-like and...