A case example of a radiation-relevant adverse outcome pathway to lung cancer

• Published in: International journal of radiation biology Vol. 97; no. 1; pp. 68 - 84
• Main Authors: Chauhan, Vinita, Sherman, Samantha, Said, Zakaria, Yauk, Carole L., Stainforth, Robert
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02.01.2021
• Subjects: Adverse outcome pathway; key event relationships; key events; lung cancer; molecular initiating event; lung cancer; key event relationships; key events; Adverse outcome pathway; molecular initiating event

Adverse outcome pathways (AOPs) describe how a measurable sequence of key events, beginning from a molecular initiator, can lead to an adverse outcome of relevance to risk assessment. An AOP is modular by design, comprised of four main components: (1) a Molecular Initiating Event (MIE), (2) Key Even...