Pyruvate Dehydrogenase Activity and Quantity Decreases After Coronary Artery Bypass Grafting: a Prospective Observational Study

• Published in: Shock (Augusta, Ga.) Vol. 43; no. 3; p. 250
• Main Authors: Andersen, Lars W, Liu, Xiaowen, Peng, Teng J, Giberson, Tyler A, Khabbaz, Kamal R, Donnino, Michael W
• Format: Journal Article
• Language: English
• Published: United States 01.03.2015
• Subjects: Aged; Coronary Artery Bypass - adverse effects; Female; Humans; Lactic Acid - blood; Male; Middle Aged; Prospective Studies; Pyruvate Dehydrogenase Complex - blood; Stress, Physiological; Thiamine - blood

Pyruvate dehydrogenase (PDH) is a key gatekeeper enzyme in aerobic metabolism. The main purpose of this study was to determine if PDH activity is affected by major stress in the form of coronary artery bypass grafting (CABG), which has previously been used as a model of critical illness. We conducte...