Unsaturated bond recognition leads to biased signal in a fatty acid receptor

• Published in: Science (American Association for the Advancement of Science) Vol. 380; no. 6640; p. eadd6220
• Main Authors: Mao, Chunyou, Xiao, Peng, Tao, Xiao-Na, Qin, Jiao, He, Qing-Tao, Zhang, Chao, Guo, Sheng-Chao, Du, Ya-Qin, Chen, Li-Nan, Shen, Dan-Dan, Yang, Zhi-Shuai, Zhang, Han-Qiong, Huang, Shen-Ming, He, Yong-Hao, Cheng, Jie, Zhong, Ya-Ni, Shang, Pan, Chen, Jun, Zhang, Dao-Lai, Wang, Qian-Lang, Liu, Mei-Xia, Li, Guo-Yu, Guo, Yongyuan, Xu, H. Eric, Wang, Chuanxin, Zhang, Cheng, Feng, Shiqing, Yu, Xiao, Zhang, Yan, Sun, Jin-Peng
• Format: Journal Article
• Language: English
• Published: United States The American Association for the Advancement of Science 07.04.2023
• Subjects: Adipogenesis; Agonists; Arrestin; Bias; Binding; Biphenyl Compounds - chemistry; Biphenyl Compounds - pharmacology; Coupling (molecular); Cryoelectron Microscopy; Drug Design; Drug development; Effectors; Eicosapentaenoic acid; Eicosapentaenoic Acid - chemistry; Eicosapentaenoic Acid - metabolism; Electron microscopy; Energy sources; Fatty acids; Fatty Acids, Omega-3 - chemistry; Fatty Acids, Omega-3 - metabolism; Fish oils; G protein-coupled receptors; Glucagon; Glucagon-like peptide 1; Hormones; Humans; Hydrophobicity; Immunological diseases; Immunosuppressive agents; Inflammation; Interfaces; Ligands; Linoleic acid; Lipids; Membrane structure; Membrane structures; Membranes; Metabolic disorders; Metabolism; Microscopy; Missense mutation; Molecular structure; Monoamines; Mutation, Missense; Nucleotides; Obesity; Oleic acid; Omega-3 fatty acids; Peptides; Phenylpropionates - chemistry; Phenylpropionates - pharmacology; Physiology; Polymorphism; Polymorphism, Single Nucleotide; Protein Conformation; Proteins; Receptors; Receptors, G-Protein-Coupled - agonists; Receptors, G-Protein-Coupled - chemistry; Receptors, G-Protein-Coupled - genetics; Recognition; Residues; Signaling; Steroid hormones; Transmission electron microscopy

Individual free fatty acids (FAs) play important roles in metabolic homeostasis, many through engagement with more than 40G protein–coupled receptors. Searching for receptors to sense beneficial omega-3 FAs of fish oil enabled the identification of GPR120, which is involved in a spectrum of metaboli...