Unsaturated bond recognition leads to biased signal in a fatty acid receptor - Mao, Chunyou; Xiao, Peng; Tao, Xiao-Na; Qin, Jiao; He, Qing-Tao; Zhang, Chao; Guo, Sheng-Chao; Du, Ya-Qin; Chen, Li-Nan; Shen, Dan-Dan; Yang, Zhi-Shuai; Zhang, Han-Qiong; et al. (Science (American Association for the Advancement of Science), 2023)
Keywords: Adipogenesis; Agonists; Arrestin; Bias; Binding; Biphenyl Compounds - chemistry; Biphenyl Compounds - pharmacology; Coupling (molecular); Cryoelectron Microscopy; Drug Design; Drug development; Effectors; Eicosapentaenoic acid; Eicosapentaenoic Acid - chemistry; Eicosapentaenoic Acid - metabolism; Electron microscopy; Energy sources; Fatty acids; Fatty Acids, Omega-3 - chemistry; Fatty Acids, Omega-3 - metabolism; Fish oils; G protein-coupled receptors; Glucagon; Glucagon-like peptide 1; Hormones; Humans; Hydrophobicity; Immunological diseases; Immunosuppressive agents; Inflammation; Interfaces; Ligands; Linoleic acid; Lipids; Membrane structure; Membrane structures; Membranes; Metabolic disorders; Metabolism; Microscopy; Missense mutation; Molecular structure; Monoamines; Mutation, Missense; Nucleotides; Obesity; Oleic acid; Omega-3 fatty acids; Peptides; Phenylpropionates - chemistry; Phenylpropionates - pharmacology; Physiology; Polymorphism; Polymorphism, Single Nucleotide; Protein Conformation; Proteins; Receptors; Receptors, G-Protein-Coupled - agonists; Receptors, G-Protein-Coupled - chemistry; Receptors, G-Protein-Coupled - genetics; Recognition; Residues; Signaling; Steroid hormones; Transmission electron microscopy