The role of GDF11 in aging and skeletal muscle, cardiac and bone homeostasis

• Published in: Critical reviews in biochemistry and molecular biology Vol. 54; no. 2; pp. 174 - 183
• Main Authors: Egerman, Marc A., Glass, David J.
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 04.03.2019
• Subjects: Aging; Animals; bone; Bone and Bones - physiology; Bone Morphogenetic Proteins - blood; Bone Morphogenetic Proteins - metabolism; cardiac muscle; GDF11; Growth Differentiation Factors - blood; Growth Differentiation Factors - metabolism; heart; Heart - physiology; Homeostasis; Humans; Muscle, Skeletal - physiology; myostatin; Myostatin - blood; Myostatin - metabolism; Skeletal muscle; GDF11; bone; aging; cardiac muscle; Skeletal muscle; heart; myostatin

GDF11 is a secreted factor in the TGFß family of cytokines. Its nearest neighbor evolutionarily is myostatin, a factor discovered as being a negative regulator of skeletal muscle growth. High profile studies several years ago suggested that GDF11 declines with age, and that restoration of systemic G...