Target mediated disposition of T84.66, a monoclonal anti-CEA antibody: Application in the detection of colorectal cancer xenografts

• Published in: mAbs Vol. 2; no. 1; pp. 67 - 72
• Main Authors: Urva, Shweta R., Balthasar, Joseph P.
• Format: Journal Article
• Language: English
• Published: United States Landes Bioscience 01.01.2010
• Subjects: Adenocarcinoma - diagnosis; Adenocarcinoma - immunology; Adenocarcinoma - metabolism; Animals; Antibodies, Monoclonal - pharmacokinetics; Binding; Biology; Bioscience; Brief Report; Calcium; Cancer; Carcinoembryonic Antigen - immunology; Carcinoembryonic Antigen - metabolism; Cell; Cell Line, Tumor; Colorectal Neoplasms - diagnosis; Colorectal Neoplasms - immunology; Colorectal Neoplasms - metabolism; Cycle; Disease Models, Animal; Humans; Landes; Metabolic Clearance Rate; Mice; Mice, Nude; Organogenesis; Prognosis; Proteins; Sensitivity and Specificity; Transplantation, Heterologous - methods; Tumor Burden - immunology

Carcinoembryonic antigen (CEA) is a glycosylated cell surface antigen known to be highly over-expressed in several adenocarcinomas, including colorectal cancer, while demonstrating limited expression in normal tissues. Prior work has shown that the plasma clearance of T84.66, a monoclonal anti-CEA a...