BatchFLEX: feature-level equalization of X-batch

• Published in: Bioinformatics (Oxford, England) Vol. 40; no. 10
• Main Authors: Davis, Joshua T, Obermayer, Alyssa N, Soupir, Alex C, Hesterberg, Rebecca S, Duong, Thac, Yang, Ching-Yao, Dao, Ken Phong, Manley, Brandon J, Grass, G Daniel, Avram, Dorina, Rodriguez, Paulo C, Fridley, Brooke L, Yu, Xiaoqing, Teng, Mingxiang, Wang, Xuefeng, Shaw, Timothy I
• Format: Journal Article
• Language: English
• Published: England Oxford University Press 01.10.2024; Oxford Publishing Limited (England)
• Subjects: Applications Note; Availability; Biological effects; Computational Biology - methods; Data analysis; DNA microarrays; Gene expression; Gene Expression Profiling - methods; Humans; Immune system; Impact analysis; Real time; RNA processing; Software

Motivation Integrative analysis of heterogeneous expression data remains challenging due to variations in platform, RNA quality, sample processing, and other unknown technical effects. Selecting the approach for removing unwanted batch effects can be a time-consuming and tedious process, especially...