Role of oxidative stress in pathophysiology of rheumatoid arthritis: insights into NRF2-KEAP1 signalling

• Published in: Autoimmunity (Chur, Switzerland) Vol. 54; no. 7; pp. 385 - 397
• Main Authors: Kaur, Gurjasmine, Sharma, Aman, Bhatnagar, Archana
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 03.10.2021; Taylor & Francis Group
• Subjects: antioxidant therapy; Antioxidants - metabolism; Antioxidants - therapeutic use; Arthritis, Rheumatoid - diagnosis; Arthritis, Rheumatoid - drug therapy; Humans; Kelch-Like ECH-Associated Protein 1 - metabolism; NF-E2-Related Factor 2 - metabolism; Nrf2-Keap1 signalling; Oxidative Stress; Rheumatoid arthritis; ROS damage; Signal Transduction; Nrf2-Keap1 signalling; ROS damage; Rheumatoid arthritis; antioxidant therapy; oxidative stress

Rheumatoid arthritis is one of the most prevalent, chronic, inflammatory disorders involving multiple articular and extra-articular complications. Immune deregulation owing to a combinatorial network of cells, inflammatory components, degrading enzymes, angiogenetic factors, exhibiting pleiotropy, s...