LncRNA GAS5 alleviates rheumatoid arthritis through regulating miR-222-3p/Sirt1 signalling axis

• Published in: Autoimmunity (Chur, Switzerland) Vol. 54; no. 1; pp. 13 - 22
• Main Authors: Yang, Zhou, Lin, Shu-Dian, Zhan, Feng, Liu, Ying, Zhan, Yu-Wei
• Format: Journal Article
• Language: English
• Published: England Taylor & Francis 02.01.2021; Taylor & Francis Group
• Subjects: autoimmune disease; lncRNA GAS5; miR-222-3p; rheumatoid arthritis; Sirt1; Sirt1; autoimmune disease; rheumatoid arthritis; miR-222-3p; lncRNA GAS5

Rheumatoid arthritis (RA) is an autoimmune disease that affects millions of people. Fibroblast-like synoviocytes (FLSs) located in rheumatoid panni play a pivotal role in the formation of RA. The long noncoding RNA (lncRNA) GAS5 is reportedly downregulated in rheumatoid arthritis. However, its detai...