Reassessment of autoreactivity of the broadly neutralizing HIV antibodies 4E10 and 2F5 and retrospective analysis of clinical safety data

• Published in: AIDS (London) Vol. 21; no. 16; pp. 2161 - 2170
• Main Authors: Vcelar, Brigitta, Stiegler, Gabriela, Wolf, Hermann M, Muntean, Wolfgang, Leschnik, Bettina, Mehandru, Saurabh, Markowitz, Martin, Armbruster, Christine, Kunert, Renate, Eibl, Martha M, Katinger, Hermann
• Format: Journal Article
• Language: English
• Published: Hagerstown, MD Lippincott Williams & Wilkins 18.10.2007
• Subjects: Adult; Antibodies, Monoclonal - administration & dosage; Antibodies, Monoclonal - immunology; Antibody Specificity; Biological and medical sciences; Blood and lymphatic vessels; Blood Coagulation Tests; Cardiolipins - immunology; Cardiology. Vascular system; Clinical Trials as Topic; Cross Reactions; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Dose-Response Relationship, Immunologic; Drug-Related Side Effects and Adverse Reactions; Enzyme-Linked Immunosorbent Assay; Female; HIV Antibodies - administration & dosage; HIV Antibodies - immunology; Human immunodeficiency virus 1; Human viral diseases; Humans; Immunization, Passive - adverse effects; Immunization, Passive - methods; Immunodeficiencies; Immunodeficiencies. Immunoglobulinopathies; Immunologic Factors - administration & dosage; Immunologic Factors - immunology; Immunopathology; Infant, Newborn; Infectious diseases; Male; Medical sciences; Phosphatidylserines - immunology; Prothrombin - immunology; Viral diseases; Viral diseases of the lymphoid tissue and the blood. Aids; British Isles, England, The Wash; Autoimmunity; Diphosphatidylglycerol; Hemostatic; HIV-1 virus; Cardiovascular disease; neutralizing antibodies; Epidemiology; Incidence; Vascular disease; Specificity; clinical safety; Immunotherapy; Thromboembolism; Human; Immunopathology; autoreactivity; Retroviridae; AIDS; Immune deficiency; Lentivirus; Thrombosis; cardiolipin; Embolism; Infection; Virus; Thromboplastin; Symptomatology; Treatment; HIV-1 infection; Viral disease; Human immunodeficiency virus; Neutralization

The broadly neutralizing recombinant human HIV-1 antibodies 4E10, 2F5 and Igh1b12 are reported to have autoreactive potential, which is significant for HIV-1 vaccine development and passive immunotherapy using these antibodies. To investigate the clinical relevance of these findings in subjects rece...