Duplicate Gene Evolution Toward Multiple Fates at the Drosophila melanogaster HIP/HIP-Replacement Locus

• Published in: Journal of molecular evolution Vol. 68; no. 4; pp. 337 - 350
• Main Authors: Hogan, Catherine C., Bettencourt, Brian R.
• Format: Journal Article
• Language: English
• Published: New York Springer-Verlag 01.04.2009; Springer Nature B.V
• Subjects: Animal Genetics and Genomics; Animals; Biomedical and Life Sciences; Cell Biology; Cofactors; Drosophila melanogaster; Drosophila melanogaster - genetics; Drosophila Proteins - genetics; Evolution; Evolution, Molecular; Evolutionary Biology; Evolutionary genetics; Gene conversion; gene duplication; Gene polymorphism; Genes; Genes, Duplicate; Genes, Insect; Genetic Variation; HSP70 Heat-Shock Proteins - genetics; Hsp70 protein; Insects; Life Sciences; Microbiology; Molecular biology; molecular evolution; Monte Carlo Method; Plant Genetics and Genomics; Plant Sciences; Polymerase Chain Reaction; Positive selection; Pseudogenes; Studies; Transcription Factors - genetics; Gene duplication; Neofunctionalization; Hsc/Hsp70-interacting protein; Concerted evolution
• ISSN: 0022-2844; 1432-1432; 1432-1432
• DOI: 10.1007/s00239-009-9213-x

Hsc/Hsp70-interacting protein (HIP) is a rapidly evolving Hsp70 cofactor. Analyses of multiple Drosophila species indicate that the HIP gene is duplicated only in D. melanogaster. The HIP region, in fact, contains seven distinctly evolving duplicated genes. The regional duplication occurred in two s...