Absorption, distribution, metabolism, and excretion of radiolabeled naldemedine in healthy subjects - Ohnishi, Shuichi; Fukumura, Kazuya; Kubota, Ryuji; Wajima, Toshihiro (Xenobiotica, 2019)
Keywords: absorption; Administration, Oral; Adult; Area Under Curve; Carbon Radioisotopes - pharmacokinetics; Constipation - chemically induced; excretion; Healthy Volunteers; Humans; Inactivation, Metabolic; Intestinal Absorption; Male; metabolism; Naldemedine; Naltrexone - administration & dosage; Naltrexone - adverse effects; Naltrexone - analogs & derivatives; Naltrexone - blood; Naltrexone - pharmacokinetics; Nausea - chemically induced; opioid-induced constipation; Oxadiazoles - chemistry; Oxadiazoles - pharmacokinetics; peripherally acting µ-opioid receptor antagonist; pharmacokinetics; Tissue Distribution; Naldemedine; excretion; absorption; opioid-induced constipation; pharmacokinetics; peripherally acting µ-opioid receptor antagonist; metabolism