Heritability and Familiality of Temperament and Character Dimensions in Korean Families with Schizophrenic Linkage Disequilibrium
Categorical syndromes such as schizophrenia may represent complexes of many continuous psychological structural phenotypes along several dimensions of personality development/degeneration. The present study investigated the heritability and familiality of personality dimensions in Korean families wi...
Saved in:
| Published in | Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology Vol. 14; no. 2; pp. 203 - 209 |
|---|---|
| Main Authors | , , , , , , |
| Format | Journal Article |
| Language | English |
| Published |
Korea (South)
Korean College of Neuropsychopharmacology
01.05.2016
대한정신약물학회 |
| Subjects | |
| Online Access | Get full text |
| ISSN | 1738-1088 2093-4327 |
| DOI | 10.9758/cpn.2016.14.2.203 |
Cover
| Abstract | Categorical syndromes such as schizophrenia may represent complexes of many continuous psychological structural phenotypes along several dimensions of personality development/degeneration. The present study investigated the heritability and familiality of personality dimensions in Korean families with schizophrenic linkage disequilibrium (LD).
We recruited 179 probands (with schizophrenia) as well as, whenever possible, their parents and siblings. We used the Temperament and Character Inventory (TCI) to measure personality and symptomatic dimensions. The heritability of personality dimensions in a total of 472 family members was estimated using Sequential Oligogenic Linkage Analysis Routines (SOLAR). To measure familiality, we compared the personality dimensions of family members with those of 336 healthy unrelated controls using analysis of variance (ANOVA) analysis.
Three of the seven TCI variables were significantly heritable and were included in subsequent analyses. The three groups (control, unaffected first-degree relative, case) were found to significantly differ from one another, with the expected order of average group scores, for all heritable dimensions.
Despite several study limitations with respect to family recruitment and phenotyping, our results show that aberrations in several personality dimensions related to genetic-environment coactions or interactions may underlie the complexity of the schizophrenic syndrome. |
|---|---|
| AbstractList | Objective: Categorical syndromes such as schizophrenia may represent complexes of many continuous psychological structural phenotypes along several dimensions of personality development/degeneration. The present study investigated the heritability and familiality of personality dimensions in Korean families with schizophrenic linkage disequilibrium (LD).
Methods: We recruited 179 probands (with schizophrenia) as well as, whenever possible, their parents and siblings. We used the Temperament and Character Inventory (TCI) to measure personality and symptomatic dimensions. The heritability of personality dimensions in a total of 472 family members was estimated using Sequential Oligogenic Linkage Analysis Routines (SOLAR).
To measure familiality, we compared the personality dimensions of family members with those of 336 healthy unrelated controls using analysis of variance (ANOVA) analysis.
Results: Three of the seven TCI variables were significantly heritable and were included in subsequent analyses. The three groups (control, unaffected first-degree relative, case) were found to significantly differ from one another, with the expected order of average group scores, for all heritable dimensions.
Conclusion: Despite several study limitations with respect to family recruitment and phenotyping, our results show that aberrations in several personality dimensions related to genetic-environment coactions or interactions may underlie the complexity of the schizophrenic syndrome. KCI Citation Count: 3 Categorical syndromes such as schizophrenia may represent complexes of many continuous psychological structural phenotypes along several dimensions of personality development/degeneration. The present study investigated the heritability and familiality of personality dimensions in Korean families with schizophrenic linkage disequilibrium (LD).OBJECTIVECategorical syndromes such as schizophrenia may represent complexes of many continuous psychological structural phenotypes along several dimensions of personality development/degeneration. The present study investigated the heritability and familiality of personality dimensions in Korean families with schizophrenic linkage disequilibrium (LD).We recruited 179 probands (with schizophrenia) as well as, whenever possible, their parents and siblings. We used the Temperament and Character Inventory (TCI) to measure personality and symptomatic dimensions. The heritability of personality dimensions in a total of 472 family members was estimated using Sequential Oligogenic Linkage Analysis Routines (SOLAR). To measure familiality, we compared the personality dimensions of family members with those of 336 healthy unrelated controls using analysis of variance (ANOVA) analysis.METHODSWe recruited 179 probands (with schizophrenia) as well as, whenever possible, their parents and siblings. We used the Temperament and Character Inventory (TCI) to measure personality and symptomatic dimensions. The heritability of personality dimensions in a total of 472 family members was estimated using Sequential Oligogenic Linkage Analysis Routines (SOLAR). To measure familiality, we compared the personality dimensions of family members with those of 336 healthy unrelated controls using analysis of variance (ANOVA) analysis.Three of the seven TCI variables were significantly heritable and were included in subsequent analyses. The three groups (control, unaffected first-degree relative, case) were found to significantly differ from one another, with the expected order of average group scores, for all heritable dimensions.RESULTSThree of the seven TCI variables were significantly heritable and were included in subsequent analyses. The three groups (control, unaffected first-degree relative, case) were found to significantly differ from one another, with the expected order of average group scores, for all heritable dimensions.Despite several study limitations with respect to family recruitment and phenotyping, our results show that aberrations in several personality dimensions related to genetic-environment coactions or interactions may underlie the complexity of the schizophrenic syndrome.CONCLUSIONDespite several study limitations with respect to family recruitment and phenotyping, our results show that aberrations in several personality dimensions related to genetic-environment coactions or interactions may underlie the complexity of the schizophrenic syndrome. Categorical syndromes such as schizophrenia may represent complexes of many continuous psychological structural phenotypes along several dimensions of personality development/degeneration. The present study investigated the heritability and familiality of personality dimensions in Korean families with schizophrenic linkage disequilibrium (LD). We recruited 179 probands (with schizophrenia) as well as, whenever possible, their parents and siblings. We used the Temperament and Character Inventory (TCI) to measure personality and symptomatic dimensions. The heritability of personality dimensions in a total of 472 family members was estimated using Sequential Oligogenic Linkage Analysis Routines (SOLAR). To measure familiality, we compared the personality dimensions of family members with those of 336 healthy unrelated controls using analysis of variance (ANOVA) analysis. Three of the seven TCI variables were significantly heritable and were included in subsequent analyses. The three groups (control, unaffected first-degree relative, case) were found to significantly differ from one another, with the expected order of average group scores, for all heritable dimensions. Despite several study limitations with respect to family recruitment and phenotyping, our results show that aberrations in several personality dimensions related to genetic-environment coactions or interactions may underlie the complexity of the schizophrenic syndrome. |
| Author | Park, Je Min Jeong, Hee Jeong Chung, Young In Yi, Young Mi Lee, Byung Dae Lee, Young Min Moon, Eunsoo |
| AuthorAffiliation | 3 Medical Research Institute, Pusan National University Hospital, Busan, Korea 1 Department of Psychiatry, Pusan National University Hospital, Busan, Korea 2 Department of Psychiatry, Pusan National University College of Medicine, Busan, Korea |
| AuthorAffiliation_xml | – name: 2 Department of Psychiatry, Pusan National University College of Medicine, Busan, Korea – name: 3 Medical Research Institute, Pusan National University Hospital, Busan, Korea – name: 1 Department of Psychiatry, Pusan National University Hospital, Busan, Korea |
| Author_xml | – sequence: 1 givenname: Byung Dae surname: Lee fullname: Lee, Byung Dae organization: Department of Psychiatry, Pusan National University Hospital, Busan, Korea, Department of Psychiatry, Pusan National University College of Medicine, Busan, Korea, Medical Research Institute, Pusan National University Hospital, Busan, Korea – sequence: 2 givenname: Je Min surname: Park fullname: Park, Je Min organization: Department of Psychiatry, Pusan National University Hospital, Busan, Korea, Department of Psychiatry, Pusan National University College of Medicine, Busan, Korea, Medical Research Institute, Pusan National University Hospital, Busan, Korea – sequence: 3 givenname: Young Min surname: Lee fullname: Lee, Young Min organization: Department of Psychiatry, Pusan National University Hospital, Busan, Korea, Department of Psychiatry, Pusan National University College of Medicine, Busan, Korea, Medical Research Institute, Pusan National University Hospital, Busan, Korea – sequence: 4 givenname: Eunsoo surname: Moon fullname: Moon, Eunsoo organization: Department of Psychiatry, Pusan National University Hospital, Busan, Korea, Department of Psychiatry, Pusan National University College of Medicine, Busan, Korea, Medical Research Institute, Pusan National University Hospital, Busan, Korea – sequence: 5 givenname: Hee Jeong surname: Jeong fullname: Jeong, Hee Jeong organization: Department of Psychiatry, Pusan National University Hospital, Busan, Korea, Medical Research Institute, Pusan National University Hospital, Busan, Korea – sequence: 6 givenname: Young In surname: Chung fullname: Chung, Young In organization: Department of Psychiatry, Pusan National University College of Medicine, Busan, Korea – sequence: 7 givenname: Young Mi surname: Yi fullname: Yi, Young Mi organization: Department of Psychiatry, Pusan National University Hospital, Busan, Korea, Medical Research Institute, Pusan National University Hospital, Busan, Korea |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/27121432$$D View this record in MEDLINE/PubMed https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002108719$$DAccess content in National Research Foundation of Korea (NRF) |
| BookMark | eNp1Uk1v1DAQtVARXUp_ABeUI5cs_kpsX5CqhdKKlZBgOVuO12nMJnZqJ6By458zu9vyJeHLzHjemzdjz1N0EmJwCD0neKlEJV_ZMSwpJvWS8CUFjz1CC4oVKzmj4gQtiGCyJFjKU3Se8xcMh6maK_YEnVJBKAHcAv24cslPpvG9n-4KE7bFpRkgMIc4tsXGDaNLZnBhOqRXnUnGTi4VbzxcZh9DLnwo3sfkTLhnu1x881NXfLKd_x7HLrngbbH2YWduHBCzu50B1iQ_D8_Q49b02Z3f2zP0-fLtZnVVrj-8u15drEsLjU4l5RJ6pgpbgitlsJGWVMy0QqmKUyoEs7RyFcxXb20t68YwURssOGvarWsNO0Mvj3VDavXOeh2NP9ibqHdJX3zcXGulJKcVQF8foePcDG5rYfZkej0mP5h0dyD-nQm-gzJfNZeVkIL-1hpTvJ1dnvTgs3V9b4KLc9ZEAJBRyvdaL_7U-iXy8EUAEEeATTHn5Fpt4cMmeHeQ9r0mWO_3QcM-6P0-aMI1BY8Bk_zDfCj-f85Pzue6ng |
| CitedBy_id | crossref_primary_10_1016_j_neuroscience_2022_05_007 crossref_primary_10_1093_schbul_sbx141 crossref_primary_10_9758_cpn_2018_16_3_302 crossref_primary_10_9758_cpn_2023_21_1_162 |
| Cites_doi | 10.1038/349704a0 10.1159/000083539 10.1001/archgenpsychiatry.2011.136 10.1002/ajmg.b.30207 10.1080/09540260400014401 10.1038/sj.mp.4001541 10.1016/j.eurpsy.2013.11.006 10.1016/S0079-6123(08)00906-0 10.1126/science.7545954 10.1016/j.psychres.2011.12.018 10.1586/17512433.2015.1040393 10.1111/j.1360-0443.2011.03617.x 10.1521/pedi.2000.14.2.99 10.1001/archpsyc.58.11.1025 10.1385/MN:32:2:173 10.1016/j.jpsychires.2014.12.013 10.1016/j.eurpsy.2006.07.002 10.1016/j.comppsych.2011.05.004 10.1176/appi.ajp.160.4.680 10.1097/NMD.0b013e3182214268 10.1023/A:1020968616616 10.1017/S1121189X00001147 10.1001/archpsyc.1994.03950110009002 10.1176/appi.ajp.2007.07101573 10.1016/j.psychres.2007.05.015 10.1111/pcn.12218 10.1016/j.biopsych.2005.01.018 10.1097/00019442-200311000-00009 10.1038/nm0605-583a 10.1016/j.biopsych.2006.05.014 10.1038/ng0503-15 10.1192/bjp.164.5.593 10.1016/j.schres.2008.06.025 10.1016/j.comppsych.2013.05.015 |
| ContentType | Journal Article |
| Copyright | Copyright © 2016, Korean College of Neuropsychopharmacology 2016 |
| Copyright_xml | – notice: Copyright © 2016, Korean College of Neuropsychopharmacology 2016 |
| DBID | AAYXX CITATION NPM 7X8 5PM ACYCR |
| DOI | 10.9758/cpn.2016.14.2.203 |
| DatabaseName | CrossRef PubMed MEDLINE - Academic PubMed Central (Full Participant titles) Korean Citation Index |
| DatabaseTitle | CrossRef PubMed MEDLINE - Academic |
| DatabaseTitleList | MEDLINE - Academic PubMed |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: https://proxy.k.utb.cz/login?url=http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Pharmacy, Therapeutics, & Pharmacology |
| EISSN | 2093-4327 |
| EndPage | 209 |
| ExternalDocumentID | oai_kci_go_kr_ARTI_998425 PMC4857872 27121432 10_9758_cpn_2016_14_2_203 |
| Genre | Journal Article |
| GrantInformation_xml | – fundername: NIBIB NIH HHS grantid: R01 EB015611 |
| GroupedDBID | --- 5-W 53G 8JR 8XY 9ZL AAFWJ AAKDD AAYXX ABDBF ABIVO ACUHS ACYCR ADBBV ADRAZ AENEX ALMA_UNASSIGNED_HOLDINGS AOIJS BAWUL CITATION DIK EBD EF. FRP GX1 HYE KQ8 M48 OK1 P5Y PGMZT RPM TUS W2D NPM 7X8 5PM |
| ID | FETCH-LOGICAL-c432t-248121290c1059a0a8c153af7995422773c25e54936dc686ba376a0743bfdefa3 |
| IEDL.DBID | M48 |
| ISSN | 1738-1088 |
| IngestDate | Sun Mar 09 07:51:22 EDT 2025 Thu Aug 21 17:34:35 EDT 2025 Thu Jul 10 18:23:00 EDT 2025 Thu Jan 02 22:58:50 EST 2025 Thu Apr 24 22:58:21 EDT 2025 Tue Jul 01 01:48:05 EDT 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 2 |
| Keywords | Schizophrenia Heritability Personality Dimension Familiality |
| Language | English |
| License | This is an Open-Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c432t-248121290c1059a0a8c153af7995422773c25e54936dc686ba376a0743bfdefa3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 G704-002231.2016.14.2.002 |
| OpenAccessLink | http://journals.scholarsportal.info/openUrl.xqy?doi=10.9758/cpn.2016.14.2.203 |
| PMID | 27121432 |
| PQID | 1785732245 |
| PQPubID | 23479 |
| PageCount | 7 |
| ParticipantIDs | nrf_kci_oai_kci_go_kr_ARTI_998425 pubmedcentral_primary_oai_pubmedcentral_nih_gov_4857872 proquest_miscellaneous_1785732245 pubmed_primary_27121432 crossref_citationtrail_10_9758_cpn_2016_14_2_203 crossref_primary_10_9758_cpn_2016_14_2_203 |
| ProviderPackageCode | CITATION AAYXX |
| PublicationCentury | 2000 |
| PublicationDate | 2016-05-01 |
| PublicationDateYYYYMMDD | 2016-05-01 |
| PublicationDate_xml | – month: 05 year: 2016 text: 2016-05-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | Korea (South) |
| PublicationPlace_xml | – name: Korea (South) |
| PublicationTitle | Clinical psychopharmacology and neuroscience : the official scientific journal of the Korean College of Neuropsychopharmacology |
| PublicationTitleAlternate | Clin Psychopharmacol Neurosci |
| PublicationYear | 2016 |
| Publisher | Korean College of Neuropsychopharmacology 대한정신약물학회 |
| Publisher_xml | – name: Korean College of Neuropsychopharmacology – name: 대한정신약물학회 |
| References | ref13 ref35 ref12 ref34 ref15 ref37 ref14 ref36 ref31 ref30 ref11 ref33 ref10 ref32 ref2 ref1 ref17 ref16 ref19 ref18 ref24 ref23 ref26 ref25 ref20 ref22 ref21 ref28 ref27 ref29 ref8 ref7 ref9 ref4 ref3 ref6 ref5 |
| References_xml | – ident: ref7 doi: 10.1038/349704a0 – ident: ref15 doi: 10.1159/000083539 – ident: ref23 doi: 10.1001/archgenpsychiatry.2011.136 – ident: ref34 doi: 10.1002/ajmg.b.30207 – ident: ref5 doi: 10.1080/09540260400014401 – ident: ref12 doi: 10.1038/sj.mp.4001541 – ident: ref19 doi: 10.1016/j.eurpsy.2013.11.006 – ident: ref28 doi: 10.1016/S0079-6123(08)00906-0 – ident: ref8 doi: 10.1126/science.7545954 – ident: ref20 doi: 10.1016/j.psychres.2011.12.018 – ident: ref9 – ident: ref29 doi: 10.1586/17512433.2015.1040393 – ident: ref24 doi: 10.1111/j.1360-0443.2011.03617.x – ident: ref31 doi: 10.1521/pedi.2000.14.2.99 – ident: ref10 doi: 10.1001/archpsyc.58.11.1025 – ident: ref30 – ident: ref2 doi: 10.1385/MN:32:2:173 – ident: ref18 doi: 10.1016/j.jpsychires.2014.12.013 – ident: ref27 doi: 10.1016/j.eurpsy.2006.07.002 – ident: ref35 doi: 10.1016/j.comppsych.2011.05.004 – ident: ref11 doi: 10.1176/appi.ajp.160.4.680 – ident: ref25 doi: 10.1097/NMD.0b013e3182214268 – ident: ref4 doi: 10.1023/A:1020968616616 – ident: ref26 doi: 10.1017/S1121189X00001147 – ident: ref32 doi: 10.1001/archpsyc.1994.03950110009002 – ident: ref6 doi: 10.1176/appi.ajp.2007.07101573 – ident: ref21 doi: 10.1016/j.psychres.2007.05.015 – ident: ref22 doi: 10.1111/pcn.12218 – ident: ref14 doi: 10.1016/j.biopsych.2005.01.018 – ident: ref3 doi: 10.1097/00019442-200311000-00009 – ident: ref17 doi: 10.1038/nm0605-583a – ident: ref13 doi: 10.1016/j.biopsych.2006.05.014 – ident: ref16 doi: 10.1038/ng0503-15 – ident: ref1 doi: 10.1192/bjp.164.5.593 – ident: ref36 doi: 10.1016/j.schres.2008.06.025 – ident: ref37 doi: 10.1016/j.comppsych.2013.05.015 – ident: ref33 |
| SSID | ssj0000396493 |
| Score | 2.0222151 |
| Snippet | Categorical syndromes such as schizophrenia may represent complexes of many continuous psychological structural phenotypes along several dimensions of... Objective: Categorical syndromes such as schizophrenia may represent complexes of many continuous psychological structural phenotypes along several dimensions... |
| SourceID | nrf pubmedcentral proquest pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | 203 |
| SubjectTerms | Original 정신과학 |
| Title | Heritability and Familiality of Temperament and Character Dimensions in Korean Families with Schizophrenic Linkage Disequilibrium |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/27121432 https://www.proquest.com/docview/1785732245 https://pubmed.ncbi.nlm.nih.gov/PMC4857872 https://www.kci.go.kr/kciportal/ci/sereArticleSearch/ciSereArtiView.kci?sereArticleSearchBean.artiId=ART002108719 |
| Volume | 14 |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| ispartofPNX | Clinical Psychopharmacology and Neuroscience, 2016, 14(2), , pp.203-209 |
| link | http://utb.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwnV3Pb9MwFLbWceGC-E35MRkJ7YCWkjiJ7Z4QGowCGppEK_VmOY49og1nNK1Ej_znvOck3YoqDpwSKXai5NnP3_fy_D1CXrmxZAaWrSgeOx5ljhfRWOQA5Mo4M0bEQhQYhzz9yiez7PM8n--RvrxV9wGbndQO60nNFpejXz_Xb2HCA34dwX3lG3OFQqYJh1k_wr1V6YDcgoWJIxc77dB-cMzpmGdBhjcRKYqaStn-59x9F9QJFgkDQMG2Fq2BX7hdePTvtMob69TJXXKnA5j0XTsi7pE96--Tw7NWoXp9RKfXG66aI3pIz661q9cPyO-JxWhByJhdU-1LGipjVAGt09rRqQWcjQldfhkuH_eCz_Q91gnA2FtDK0-_1IBGfdfbNhTjvfTbjQw_Q5EGgzeDjpjPXYXNB6sfD8ns5MP0eBJ1VRoiA19mGbEMMAJGswxCNR1racCLaheU5hgTIjUst0BDU14aLnmhwadpRC6FK63T6SOy72tvnxCaJwVQZqZdCaywSKzUuStM5oyDU27LIYl7MyjTSZhjJY1LBVQGjajAiAqNCIxGMThLh-T1pstVq9_xr8YvwbbqwlQKVbfxeF6ri4UCbvFJATEFBwdtessrmIn4e0V7W68alQiZC_CPGbR53I6EzSP7gTQkYmuMbBrg87av-Op7UPvOJDpV9vS_ez4jt_Et2yzN52R_uVjZF4CklsUBGXycJwdhlvwBfeQevQ |
| linkProvider | Scholars Portal |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Heritability+and+Familiality+of+Temperament+and+Character+Dimensions+in+Korean+Families+with+Schizophrenic+Linkage+Disequilibrium&rft.jtitle=Clinical+psychopharmacology+and+neuroscience+%3A+the+official+scientific+journal+of+the+Korean+College+of+Neuropsychopharmacology&rft.au=Lee%2C+Byung+Dae&rft.au=Park%2C+Je+Min&rft.au=Lee%2C+Young+Min&rft.au=Moon%2C+Eunsoo&rft.date=2016-05-01&rft.pub=Korean+College+of+Neuropsychopharmacology&rft.issn=1738-1088&rft.eissn=2093-4327&rft.volume=14&rft.issue=2&rft.spage=203&rft.epage=209&rft_id=info:doi/10.9758%2Fcpn.2016.14.2.203&rft_id=info%3Apmid%2F27121432&rft.externalDocID=PMC4857872 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1738-1088&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1738-1088&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1738-1088&client=summon |