Artificial intelligence identified peptides modulate inflammation in healthy adults

• Published in: Food & function Vol. 1; no. 9; pp. 63 - 641
• Main Authors: Rein, Dietrich, Ternes, Philipp, Demin, Rodion, Gierke, Jürgen, Helgason, Thrandur, Schön, Christiane
• Format: Journal Article
• Language: English
• Published: England Royal Society of Chemistry 01.09.2019
• Subjects: absorption; Adolescent; Adult; adults; Algorithms; Artificial Intelligence; Biological activity; Biomarkers - blood; blood; Chromatography, Liquid; Computer simulation; Cytokines; Dietary supplements; Docking; Enzyme-linked immunosorbent assay; Female; Humans; Immunologic Factors - administration & dosage; Immunologic Factors - chemistry; Immunomodulation; immunomodulators; Inflammation; Inflammation - blood; Inflammation - drug therapy; Inflammation - immunology; Interleukin 10; Interleukin 6; Interleukin 8; Interleukin-10 - blood; Interleukin-10 - immunology; Interleukin-6 - blood; Interleukin-6 - immunology; Intestine; intestines; IP-10 protein; liquid chromatography; Male; Markers; Middle Aged; Monocyte chemoattractant protein 1; nitrogen oxides; Oryza; Oryza - chemistry; Peptides; Peptides - administration & dosage; Peptides - chemistry; protein hydrolysates; Protein Hydrolysates - administration & dosage; Protein Hydrolysates - chemistry; Proteins; Rice; rice protein; Tandem Mass Spectrometry; tumor necrosis factor-alpha; Tumor Necrosis Factor-alpha - blood; Tumor Necrosis Factor-alpha - immunology; Tumor necrosis factor-α; Young Adult

Dietary bioactive peptides have been, among many functionalities, associated with immune modulation and thereby may improve resolution of inflammation. The goals of this research were to assess (1) whether specific peptides with immune-modulating activity consumed as part of a rice protein hydrolysa...