Pathophysiological importance of antineutrophil antibodies in vasculitis

• Published in: Current opinion in hematology Vol. 18; no. 1; p. 25
• Main Authors: Basu, Neil, Erwig, Lars-Peter
• Format: Journal Article
• Language: English
• Published: United States 01.01.2011
• Subjects: Animals; Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis - immunology; Antibodies, Antineutrophil Cytoplasmic - immunology; Antibody Specificity - immunology; Complement Activation - immunology; Complement System Proteins - immunology; Humans; Lymphocyte Activation - immunology; Lysosomal-Associated Membrane Protein 2 - immunology; T-Lymphocyte Subsets - immunology; Vasculitis - immunology

We endeavour to provide a brief overview of the recent advances in understanding of how antineutrophil cytoplasmic antibodies (ANCAs) contribute to the pathophysiology of vasculitis. Substantial progress has been made in our understanding of the immunopathogenesis of ANCA-associated vasculitides. Co...