Factor analysis of obsessive-compulsive disorder YBOCS-SC symptoms and association with 5-HTTLPR SERT polymorphism

Symptoms defining obsessive–compulsive disorder (OCD) are diverse. Factor analyses of OCD symptoms have been used to evaluate obsessive–compulsive phenotypes that are thought to be more homogenous than the macro phenotype. There is evidence that three factors (symmetry/ordering, obsessions/checking,...

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Published inAmerican journal of medical genetics. Part B, Neuropsychiatric genetics Vol. 141B; no. 4; pp. 403 - 408
Main Authors Hasler, Gregor, Kazuba, Diane, Murphy, Dennis L.
Format Journal Article
LanguageEnglish
Published Hoboken Wiley Subscription Services, Inc., A Wiley Company 05.06.2006
Wiley-Liss
Subjects
Adult
Aged
Aged, 80 and over
Alleles
Biological and medical sciences
endophenotype
factor analysis
Factor Analysis, Statistical
Female
Gene Frequency
Genotype
Humans
Male
Medical genetics
Medical sciences
Middle Aged
Obsessive-Compulsive Disorder - genetics
Obsessive-Compulsive Disorder - psychology
Polymorphism, Genetic
Promoter Regions, Genetic - genetics
Serotonin Plasma Membrane Transport Proteins - genetics
serotonin transporter
symptom cluster
Obsessive compulsive disorder
Symptomatology
Association
Analysis
Anxiety disorder
Polymorphism
Online AccessGet full text
ISSN1552-4841
1552-485X
DOI10.1002/ajmg.b.30309

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Abstract Symptoms defining obsessive–compulsive disorder (OCD) are diverse. Factor analyses of OCD symptoms have been used to evaluate obsessive–compulsive phenotypes that are thought to be more homogenous than the macro phenotype. There is evidence that three factors (symmetry/ordering, obsessions/checking, and hoarding) are familial and preliminary evidence that repetitive rituals are associated with a functional polymorphism in the promotor region of the serotonin transporter gene (5‐HTTLPR). The goal of this study was to examine relationships between OCD symptom dimensions and 5‐HTTLPR. We genotyped 153 subjects who met DSM‐IV criteria for OCD. We used the Yale‐Brown obsessive–compulsive scale symptom checklist (YBOCS‐SC) to assess OCD symptoms. Using principle components analysis, we derived four factors from the 13 symptom categories of the YBOCS‐SC in this patient sample, which replicated previous factor analyses of this scale. The frequencies of the S allele and the SS genotype were associated with the second factor including obsessions regarding symmetry and compulsions involving repeating, counting, and ordering/arranging. This study may contribute to understanding of molecular genetic features underlying the appearance of symptom clusters in OCD. © 2006 Wiley‐Liss, Inc.
AbstractList Symptoms defining obsessive-compulsive disorder (OCD) are diverse. Factor analyses of OCD symptoms have been used to evaluate obsessive-compulsive phenotypes that are thought to be more homogenous than the macro phenotype. There is evidence that three factors (symmetry/ordering, obsessions/checking, and hoarding) are familial and preliminary evidence that repetitive rituals are associated with a functional polymorphism in the promotor region of the serotonin transporter gene (5-HTTLPR). The goal of this study was to examine relationships between OCD symptom dimensions and 5-HTTLPR. We genotyped 153 subjects who met DSM-IV criteria for OCD. We used the Yale-Brown obsessive-compulsive scale symptom checklist (YBOCS-SC) to assess OCD symptoms. Using principle components analysis, we derived four factors from the 13 symptom categories of the YBOCS-SC in this patient sample, which replicated previous factor analyses of this scale. The frequencies of the S allele and the SS genotype were associated with the second factor including obsessions regarding symmetry and compulsions involving repeating, counting, and ordering/arranging. This study may contribute to understanding of molecular genetic features underlying the appearance of symptom clusters in OCD.
Symptoms defining obsessive–compulsive disorder (OCD) are diverse. Factor analyses of OCD symptoms have been used to evaluate obsessive–compulsive phenotypes that are thought to be more homogenous than the macro phenotype. There is evidence that three factors (symmetry/ordering, obsessions/checking, and hoarding) are familial and preliminary evidence that repetitive rituals are associated with a functional polymorphism in the promotor region of the serotonin transporter gene (5‐HTTLPR). The goal of this study was to examine relationships between OCD symptom dimensions and 5‐HTTLPR. We genotyped 153 subjects who met DSM‐IV criteria for OCD. We used the Yale‐Brown obsessive–compulsive scale symptom checklist (YBOCS‐SC) to assess OCD symptoms. Using principle components analysis, we derived four factors from the 13 symptom categories of the YBOCS‐SC in this patient sample, which replicated previous factor analyses of this scale. The frequencies of the S allele and the SS genotype were associated with the second factor including obsessions regarding symmetry and compulsions involving repeating, counting, and ordering/arranging. This study may contribute to understanding of molecular genetic features underlying the appearance of symptom clusters in OCD. © 2006 Wiley‐Liss, Inc.
Symptoms defining obsessive-compulsive disorder (OCD) are diverse. Factor analyses of OCD symptoms have been used to evaluate obsessive-compulsive phenotypes that are thought to be more homogenous than the macro phenotype. There is evidence that three factors (symmetry/ordering, obsessions/checking, and hoarding) are familial and preliminary evidence that repetitive rituals are associated with a functional polymorphism in the promotor region of the serotonin transporter gene (5-HTTLPR). The goal of this study was to examine relationships between OCD symptom dimensions and 5-HTTLPR. We genotyped 153 subjects who met DSM-IV criteria for OCD. We used the Yale-Brown obsessive-compulsive scale symptom checklist (YBOCS-SC) to assess OCD symptoms. Using principle components analysis, we derived four factors from the 13 symptom categories of the YBOCS-SC in this patient sample, which replicated previous factor analyses of this scale. The frequencies of the S allele and the SS genotype were associated with the second factor including obsessions regarding symmetry and compulsions involving repeating, counting, and ordering/arranging. This study may contribute to understanding of molecular genetic features underlying the appearance of symptom clusters in OCD.Symptoms defining obsessive-compulsive disorder (OCD) are diverse. Factor analyses of OCD symptoms have been used to evaluate obsessive-compulsive phenotypes that are thought to be more homogenous than the macro phenotype. There is evidence that three factors (symmetry/ordering, obsessions/checking, and hoarding) are familial and preliminary evidence that repetitive rituals are associated with a functional polymorphism in the promotor region of the serotonin transporter gene (5-HTTLPR). The goal of this study was to examine relationships between OCD symptom dimensions and 5-HTTLPR. We genotyped 153 subjects who met DSM-IV criteria for OCD. We used the Yale-Brown obsessive-compulsive scale symptom checklist (YBOCS-SC) to assess OCD symptoms. Using principle components analysis, we derived four factors from the 13 symptom categories of the YBOCS-SC in this patient sample, which replicated previous factor analyses of this scale. The frequencies of the S allele and the SS genotype were associated with the second factor including obsessions regarding symmetry and compulsions involving repeating, counting, and ordering/arranging. This study may contribute to understanding of molecular genetic features underlying the appearance of symptom clusters in OCD.
Author Hasler, Gregor
Murphy, Dennis L.
Kazuba, Diane
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  fullname: Murphy, Dennis L.
  organization: Laboratory of Clinical Science, National Institute of Mental Health, National Institutes of Health, Bethesda
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Keywords Obsessive compulsive disorder
Symptomatology
Association
Analysis
Anxiety disorder
Polymorphism
Language English
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Please cite this article as follows: Hasler G, Kazuba D, Murphy DL. 2006. Factor Analysis of Obsessive-Compulsive Disorder YBOCS-SC Symptoms and Association With 5-HTTLPR SERT Polymorphism. Am J Med Genet Part B 141B:403-408.
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Please cite this article as follows: Hasler G, Kazuba D, Murphy DL. 2006. Factor Analysis of Obsessive–Compulsive Disorder YBOCS‐SC Symptoms and Association With 5‐HTTLPR SERT Polymorphism. Am J Med Genet Part B 141B:403–408.
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PublicationTitle American journal of medical genetics. Part B, Neuropsychiatric genetics
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Snippet Symptoms defining obsessive–compulsive disorder (OCD) are diverse. Factor analyses of OCD symptoms have been used to evaluate obsessive–compulsive phenotypes...
Symptoms defining obsessive-compulsive disorder (OCD) are diverse. Factor analyses of OCD symptoms have been used to evaluate obsessive-compulsive phenotypes...
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StartPage 403
SubjectTerms Adult
Aged
Aged, 80 and over
Alleles
Biological and medical sciences
endophenotype
factor analysis
Factor Analysis, Statistical
Female
Gene Frequency
Genotype
Humans
Male
Medical genetics
Medical sciences
Middle Aged
Obsessive-Compulsive Disorder - genetics
Obsessive-Compulsive Disorder - psychology
Polymorphism, Genetic
Promoter Regions, Genetic - genetics
Serotonin Plasma Membrane Transport Proteins - genetics
serotonin transporter
symptom cluster
Title Factor analysis of obsessive-compulsive disorder YBOCS-SC symptoms and association with 5-HTTLPR SERT polymorphism
URI https://api.istex.fr/ark:/67375/WNG-CXZHH7QK-M/fulltext.pdf
https://onlinelibrary.wiley.com/doi/abs/10.1002%2Fajmg.b.30309
https://www.ncbi.nlm.nih.gov/pubmed/16583440
https://www.proquest.com/docview/19731529
https://www.proquest.com/docview/68004798
Volume 141B
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