Harnessing mesenchymal aggregation for engineered organ‐level regeneration: Recent progress and perspective

• Published in: Aggregate (Hoboken) Vol. 5; no. 2
• Main Authors: Zheng, Chen‐Xi, Sui, Bing‐Dong, Jin, Yan
• Format: Journal Article
• Language: English
• Published: Guangzhou John Wiley & Sons, Inc 01.04.2024; Wiley
• Subjects: Aggregates; Cartilage; Cell cycle; Exocrine glands; Follicles; Genetic engineering; Kinases; Ligands; mesenchymal aggregation; Morphogenesis; organ regeneration; organogenesis; Principles; Stem cells

Stem cells, especially mesenchymal progenitors or mesenchymal stem cells (MSCs), possess an intrinsic property to form compact spheroid‐like assemblies, a phenomenon known as cell aggregation. In recent years, a growing body of researches have uncovered that this is a cross‐species conserved develop...