α6-Integrin Subunit Plays a Major Role in the Proangiogenic Properties of Endothelial Progenitor Cells

• Published in: Arteriosclerosis, thrombosis, and vascular biology Vol. 30; no. 8; pp. 1569 - 1575
• Main Authors: Bouvard, Claire, Gafsou, Benjamin, Dizier, Blandine, Galy-Fauroux, Isabelle, Lokajczyk, Anna, Boisson-Vidal, Catherine, Fischer, Anne-Marie, Helley, Dominique
• Format: Journal Article
• Language: English
• Published: Philadelphia, PA American Heart Association, Inc 01.08.2010; Lippincott Williams & Wilkins
• Subjects: Atherosclerosis (general aspects, experimental research); Biological and medical sciences; Blood and lymphatic vessels; Blood vessels and receptors; Cardiology. Vascular system; Diseases of the peripheral vessels. Diseases of the vena cava. Miscellaneous; Fundamental and applied biological sciences. Psychology; Medical sciences; Vertebrates: cardiovascular system; Endothelial cell; Cardiovascular disease; peripheral arterial disease; vascular biology; Arterial disease; Vascular disease; Angiogenesis; Integrin; Ischemia; adhesion molecules; Atherosclerosis; Occlusive arterial disease; Progenitor cell

OBJECTIVE—Alpha6 integrin subunit (α6) expression is increased by proangiogenic growth factors such as vascular endothelial growth factor (VEGF) and fibroblast growth factor. This increase correlates with enhanced in vitro tube formation by endothelial cells and their progenitors called Endothelial...