Logistics and quality control for DNA sampling in large multicenter studies

• Published in: Journal of thrombosis and haemostasis Vol. 1; no. 5; pp. 987 - 991
• Main Authors: Nederhand, R. J., Droog, S., Kluft, C., Simoons, M. L., De Maat, M. P. M.
• Format: Journal Article
• Language: English
• Published: Oxford, UK Blackwell Science Inc 01.05.2003
• Subjects: Blood Banking - methods; Blood Banks - standards; Blood Cells; Blood Specimen Collection - methods; Blood Specimen Collection - standards; clinical trial; DNA - isolation & purification; DNA isolation; Humans; Organization and Administration; Preservation, Biological - methods; Preservation, Biological - standards; Quality Control; Temperature; Time Factors; Transportation - standards

To study associations between genetic variation and disease, large bio‐banks need to be created in multicenter studies. Therefore, we studied the effects of storage time and temperature on DNA quality and quantity in a simulation experiment with storage up to 28 days frozen, at 4 °C and at room temp...