Chronic liver disease in kidney recipients with hepatitis C virus infection

• Published in: Clinical transplantation Vol. 17; no. 3; pp. 195 - 199
• Main Authors: Giordano, Helena M, França, Alex VC, Meirelles, Luciana, Escanhoela, Cecília AF, Nishimura, Nancy F, Santos, Raquel LS, Quadros, Kélcia RS, Mazzali, Marilda, Alves-Filho, Gentil, Soares, Elza C
• Format: Journal Article
• Language: English
• Published: Oxford, UK Munksgaard International Publishers 01.06.2003; Blackwell
• Subjects: Adult; Alanine Transaminase - blood; Biological and medical sciences; Biopsy; Case-Control Studies; Enzyme-Linked Immunosorbent Assay; Female; Hepatitis C Antibodies - analysis; hepatitis C virus; Hepatitis C, Chronic - etiology; Hepatitis C, Chronic - pathology; Human viral diseases; Humans; Immunosuppression; Infectious diseases; Kidney Transplantation; Liver - pathology; liver histology; Male; Medical sciences; Polymerase Chain Reaction; renal transplantation; Time Factors; Viral diseases; Viral hepatitis; Kidney disease; Human; renal transplantatior; Urinary system disease; Prognosis; Hepatic disease; Transplantation; Kidney; Infection; Chronic; Surgery; Viral disease; liver histology; hepatitis C virus; Digestive diseases; Graft; Comparative study; Viral hepatitis C
• ISSN: 0902-0063; 1399-0012
• DOI: 10.1034/j.1399-0012.2003.00025.x

: Background:  The prevalence of anti‐hepatitis C virus (HCV) positive test is higher among patients in dialysis and in kidney recipients than in general population. Hepatitis C virus infection is the main cause of chronic liver disease in renal transplant patients. Liver biopsy and virological analysis were performed to clarify the grade of liver damage in kidney recipients. Methods:  Renal recipients patients with at least 5 yr under immunosuppression were submitted to clinical and laboratory analysis. Patients who tested anti‐HCV positive were candidates to liver biopsy with no regard to transaminase levels. Results:  Forty‐five patients tested anti‐HCV positive and 42 anti‐HCV negative. Twenty‐six anti‐HCV and RNA‐HCV positive patients were submitted to liver biopsy. Seventy‐three percentage of these patients presented chronic active hepatitis, from these only one patient presented cirrhosis. Only 29% of the anti‐HCV positive group presented elevated alanine aminotransferase levels. Anti‐HCV positive patients presented longer previous time on dialysis and less rejection episodes than the group anti‐HCV negative (p < 0.05). All anti‐HCV positive patients but one tested RNA‐HCV positive by polymerase chain reaction (PCR). Conclusions:  In this series the prevalence of anti‐HCV positive is 51.7%. Most of the patients presented liver damage in histology caused by HCV. However, we found only mild or minimal fibrosis and inflammatory activity grade, despite 10 yr of HCV infection and 5 yr of immunosuppressive treatment. Only one patient presented cirrhosis (4%). Performing serial liver biopsies in a long‐term follow‐up is needed to clarify the impact of HCV infection in renal transplant patients.